Tools for Lung Cancer Research

Recent advances in lung cancer research suggest a personalized approach to diagnostics and therapeutics to reduce mortality

Due to its high rate of mortality, lung cancer is a prominent area of research for scientists. Lung cancer is a complex disease with many subtypes resulting from factors such as family history, lifestyle and occupation-with each subtype requiring different treatment regimens. Thus, developing therapeutics for this disease requires vast research efforts.

The specific subtypes of the cancer must be paired to successful treatments, which can then be matched to individual patients. The American Type Culture Collection (ATCC) has responded to this initiative for personalized medicine by creating new drug screening and diagnostic test development tools, such as tumor cell panels based on genetic alteration, primary cells, gene-edited isogenic cell lines and cell line derivatives.

"Over the years, we have expanded our portfolio into the most diverse and unique collection of cancer cells to include thousands of human and animal cancer cell lines representing the diversity of the disease," said Fang Tian, PhD, lead scientist at ATCC. "Our growing collection of lung cancer cell lines is now just shy of 100 lines.

Read more: Tools for Lung Cancer Research

Source: laboratory-manager.advanceweb

Fasting no longer necessary before cholesterol test

For the first time, a team of international experts recommends that most people do not need to fast before having their cholesterol and triglyceride levels tested.

Fasting is a problem for many patients, they explain, and note the latest research shows that cholesterol and triglyceride levels are similar whether people fast or not.

The experts represent the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative.

They refer to new research from Denmark, Canada, and the United States that included over 300,000 people and found it is not necessary to have an empty stomach to check cholesterol levels.

Apart from Denmark, all countries require that patients fast for at least 8 hours before checking their cholesterol and triglyceride levels - referred to as "lipid profile." In Denmark, non-fasting blood sampling has been in use since 2009.

Read more: Fasting no longer necessary before cholesterol test

Researchers say fasting before a cholesterol test is unnecessary.

Source: medicalnewstoday

Building a career in the biomedical laboratory sciences.

Passion is the key to success, says Jim Smith in his keynote speech at the London NatureJobs Career Expo.

Jim Smith is a successful scientist by anyone’s measure. The UK scientist helped discover key growth factors required for the early development of embryos, and has received numerous awards for his scientific contributions. Smith now juggles three high-level roles at the UK Medical Research Council (MRC), National Institute of Medical Research and the soon-to-be-opened Francis Crick Institute in London with the running of his own lab at the MRC.

Like many people who have excelled in their field, Smith’s career has the illusion of being planned from the start. However he says this was not the case. He didn’t study biology until he was persuaded to take a cell biology class at the University of Cambridge while studying for a degree in natural sciences.

He fell so in love with the subject that he progressed to a PhD studentship with the famous development biologist Lewis Wolport. “You should allow yourself to fall in love with your subject, become engrossed by it,” Smith says. This passion is a key to success he stresses, because it drives you to put the necessary effort in. “There are times in your career when you know that working twice as hard will produce double the results, at these times you should work 3 or 4 times as hard,” Smith says.

Finding the ‘niche’ in science that you are most passionate about can be challenging.

Read more: Building a career in the biomedical laboratory sciences.

Source: naturejobs

Pondering my PhD worth after graduation.

Her PhD on Parkinson’s disease didn’t go exactly as planned, but in the end the difficulties made Liesbeth Aerts a happier scientist.

One year ago today, I found myself in a lecture theatre, presenting my research to a thesis jury. During the years leading up to that moment, there were many days when I worried whether I was ever going to make it that far. When I finally did, most of all, I felt relieved.

Like many others, I had imagined my PhD differently. I was prepared for the hard work and long hours. I thought that if I gave it my all, I would be a successful scientist. My ambitions took a blow when faced with failure after failure. For well over a year, I felt like a fraud, having fooled my supervisors and myself into thinking that I had what it took to become a good scientist. Looking back, I’d tell my younger self to take it easy.

Cut yourself some slack

Even Nobel prize winners were first-year students once. They messed up their experiments, needed help and most likely suffered just as much as you did. Don’t expect to do everything right the first time around. No matter how hard you work and how motivated you are, you’ll need to accept that becoming better takes time and requires failure.

One mistake at a time, I got better, and as time went by, I realised others were making educated guesses just like I was. They too didn’t understand everything during seminars. Could it be that, just maybe, I wasn’t the dumbest person in the room?

Read more: Pondering my PhD worth after graduation.

Source: blogs.nature.com