Biomedical Laboratory Science

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Sunday, July 17, 2016

Fluctuating Serum Aspartate Aminotransferase Activity in a Complicated Pregnancy

Clinical Case Study
A 29-year-old para 0 gravida 2 woman with a history of infertility and spontaneous abortion presented to her local hospital at 9 weeks gestation with severe nausea and vomiting. Symptoms persisted for 10 weeks, leading to the diagnosis of hyperemesis gravidarum and treatment with intravenous fluids (3 times/week) and Zofran.

At 8 weeks gestation, laboratory tests were unremarkable with the exception of increased aspartate aminotransferase (AST)5 measured at a regional reference laboratory [105 U/L; reference interval (RI), 10 – 40 U/L]. AST continued to be monitored at the same laboratory, peaking at 132 U/L (9 weeks gestation) and gradually declining to 38 U/L by 19 weeks gestation.


uqccr/hepcarepharmacy
Source: clinchem

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