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Saturday, August 13, 2016

Osteoarthritis can be Caused by Senescent Cells

Researchers have uncovered evidence that cellular senescence - whereby cells stop dividing - is a cause of osteoarthritis, and they suggest targeting these cells could offer a promising way to prevent or treat the condition.

Study co-author Dr. James Kirkland, director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic in Rochester, MN, and colleagues publish their findings in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.

Osteoarthritis (OA), also known as degenerative joint disease, is a condition in which cartilage - the tissue that protects the end of each bone in a joint - wears away, causing the underlying bones to rub together. This can cause pain, swelling, and poor joint movement.

As the condition worsens, the bones may lose shape. Additionally, growths called bone spurs may arise, and bits of bone and cartilage can break off and float around the space in the joint. This can trigger an inflammatory response that exacerbates pain, as well as cartilage and bone damage.


Researchers say that targeting senescent cells may have the potential to prevent or treat osteoarthritis.
Source: medicalnewstoday

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