Some Breast Cancers Fail to Respond to Treatments, Why?

Breast Cancer

Most breast cancers are estrogen receptor-positive, meaning that signals received from estrogen, a hormone, promote the growth of the tumors. To stop these cancers from spreading, estrogen inhibitors are usually prescribed. But what happens when tumors develop treatment resistance?

Studies suggest that "approximately 70 percent" of all the breast cancers are estrogen receptor-positive (ER-positive).

These types of cancer are typically treated with drugs — such as tamoxifen and fulvestrant — that either lower the levels of the hormone or inhibit the estrogen receptors to prevent the tumors from spreading. This is known as endocrine therapy.

However, around a third of the people treated with these drugs develop resistance to them, which negatively impacts their chances of survival. The mechanisms that underlie the tumors' resistance to therapy is not well understood and currently poses a major challenge.

Read More »

Study Sheds Light on How High Cholesterol Causes Cancer !

Cholesterol

New research from the University of California, Los Angeles has found a previously unknown molecular mechanism involving cholesterol that may promote tumor growth in the intestines.

A report on the study — published in the journal Cell Stem Cell — reveals how increasing levels of cholesterol in mice increased proliferation of intestinal stem cells and made tumors grow faster.

One of the methods that the researchers used to increase the availability of cholesterol to intestinal cells in the mice was to feed them a high-cholesterol diet.

"We were excited to find," says senior author Peter Tontonoz, a professor of pathology and laboratory medicine, "that cholesterol influences the growth of stem cells in the intestines, which in turn accelerates the rate of tumor formation by more than 100-fold."

He and his colleagues believe that their findings could pave the way to new treatments for gastrointestinal diseases, such as colon cancer.

Read More »

Watch Video »

Cancer: Shutting Down Fat Synthesis In Cancer Cells Stunts Tumor Growth

Tumors have a voracious appetite for fat and rely on hastened fat synthesis in cancer cells to satisfy their need. Now, a new study shows it is possible to use drugs to shut down fat synthesis in cancer cells to stunt tumor growth without harming healthy cells.

A report on the study is published in the journal Nature Medicine.

The discovery - by researchers at the Salk Institute in La Jolla, CA, and collaborators - represents a new frontier in the search for targeted treatments against cancer, a leading cause of disease and premature death worldwide.

Read more: Cancer: Shutting Down Fat Synthesis In Cancer Cells Stunts Tumor Growth

The researchers found cells treated with a placebo produced more fat (red, on left) than cells treated

with the enzyme inhibitor (right). Image credit: Salk Institute

Source: medicalnewstoday

New 'Mutation-Tracking' Blood Test Could Predict Breast Cancer Relapse Months in Advance

Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans.

The test can uncover small numbers of residual cancer cells that have resisted therapy by detecting cancer DNA in the bloodstream.

Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust were able to track key mutations that cancer accumulates as it develops and spreads, without the need for invasive biopsy procedures.

They hope that by deciphering the DNA code found in blood samples, it should be possible to identify the particularly mutations likely to prove lethal to that patient - and tailor treatment accordingly.

Read more: New 'Mutation-Tracking' Blood Test Could Predict Breast Cancer Relapse Months in Advance

Source: medicalxpress

What is Cancer?

A Collection of Related Diseases

Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.

Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and divide to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.

When cancer develops, however, this orderly process breaks down. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells form when they are not needed. These extra cells can divide without stopping and may form growths called tumors.

Many cancers form solid tumors, which are masses of tissue. Cancers of the blood, such as leukemias, generally do not form solid tumors.

Cancerous tumors are malignant, which means they can spread into, or invade, nearby tissues. In addition, as these tumors grow, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumors far from the original tumor.

Read more: What is Cancer?

Normal cells may become cancer cells.

Source: cancer.gov

New nanoparticle 'cluster bombs' could make chemotherapy less toxic.

Chemotherapy is one of the key weapons in our fight against cancer, but it comes with a whole host of unwanted side effects and damage to the surrounding, healthy areas of the body. So an international team of researchers has come up with what they think could be a much less toxic way of delivering the treatment, and it's based around 'cluster bombs' of nanoparticles.

The new procedure is designed to improve the delivery of the chemotherapy drug cisplatin. It works using tiny nanoparticles, just 100 nanometres wide, which are loaded with drugs and transported to the tumor site through blood vessels. Once they reach their destination, the acidic environment around the cancer cells causes them to break up into 5-nanometre-wide particles, which can then move inside the tumor cells.

At this point, the cisplatin can do its work from inside the tumor cells, damaging the cancerous DNA to effectively kill them off. To give you some idea of the scale, you can fit a million nanometres inside a millimetre.

In tests on lab mice, the teams from Emory University in the US and the University of Science and Technology of China found that the concentration of cisplatin that reached the tumors was seven times higher than normal. And if more of the drug is reaching its intended target, that means less of it is leaking out into the rest of the body, so unwanted side effects are reduced.

Video source: New nanoparticle 'cluster bombs' could make chemotherapy less toxic.

Source: Jovan Vitanovski/Shutterstock