Biomedical Laboratory Science

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Wednesday, June 8, 2016

Circulating Tumor Cells (CTCs)

Your doctor may order a test for circulating tumor cells (CTCs) to help guide your cancer care.

One of the major challenges in treating cancer is getting “all” of the cancer, including the parts we cannot see. Even if surgery, chemotherapy, or radiation removes all traces of known cancer, there is still a risk of the cancer returning, often in a distant location in the body. This may occur as a result of CTCs.

Circulating tumor cells were first found in the blood under the microscope nearly 150 years ago. They are cancer cells from the primary tumor that escaped into the bloodstream to circulate around the body. As a result, these cells can serve as seeds for new areas of cancer to grow in distant organs. This is known asmetastasis.

Not all CTCs have the ability to land and establish a new metastasis in a distant organ; some may remain dormant (inactive) or be controlled by the immune system for years, sometimes forever.



Source: jamanetwork

Tuesday, June 7, 2016

A Scientific Approach to Scientific Writing

This guide provides a framework, starting from simple statements, for writing papers for submission to peer-reviewed journals. It also describes how to address referees’ comments, approaches for composing other types of scientific communications, and key linguistic aspects of scientific writing.

Essential Steps Before Writing a Paper
Having completed a study and acquired all the data required to present it, you are ready to begin preparing a paper. However, before beginning to write, you have to take several critical preliminary steps: Your notes must be gathered, a suitable place for writing must be found, a selective literature review may be helpful, a target journal must be identified, linguistic limitations must be recognized, the study must be defined and delimited, and the information must be arranged. Failure to take these steps will make writing more difficult and seriously compromise the chances of publication. Therefore, this chapter outlines what needs to be done in each of these steps.



Download here: 1. www.victoria.ac.nz
                           2. books.google.com.np

Sunday, June 5, 2016

MCQ 4. A 60 year old man is diagnosed with a MALToma. This is attributed to a translocation involving MALT1 and a gene.


MCQ 4. A 60 year old man is diagnosed with a MALToma. This is attributed to a translocation involving MALT1 and a gene.

Which is this gene?
a. BCL1
b. BCL2
c. BCL6
d. BCL10
e. BCL12

Correct answer: Click here

MCQ 3: What is the normal average life span of red blood cells in our body?


3. What is the normal average life span of red blood cells in our body?
a. 10 days
b. 120 days
c. 240 days
d. 360 days

Correct answer link: Click here

Saturday, June 4, 2016

Cholesterol: Types, Treatments, and Lifestyle Changes



Source: Healthline Networks

What Do You Want to Know About High Cholesterol?

Cholesterol is a substance that your liver produces naturally. It’s vital for the formation of cell membranes, vitamin D, and certain hormones.

Cholesterol is a waxy, fat-like substance. It doesn’t dissolve in water and therefore can't travel through the blood by itself. Lipoproteins are other particles formed in the liver that help transport cholesterol through the bloodstream. There are several major forms of lipoproteins that are important to your health.


Thursday, June 2, 2016

Medical Video: How to Perform Endotracheal Intubation.

Prepare for emergency and watch this fascinating animated video to learn how to perform neonatal endotracheal incubation.


Source: MedicalVideos

Monday, May 30, 2016

Medical Video: How does insulin work in the body

Take a trip inside the body in this fascinating animated video to find out how insulin works in the body.



Source: MedicalVideos

New Gene Associated With Familial High Cholesterol

The gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol has been revealed. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people.

The reason why lipoprotein(a) concentrations are raised in individuals with clinical familial hypercholesterolemia is unclear. The hypotheses that high lipoprotein(a) cholesterol and LPA risk genotypes are a possible cause of clinical familial hypercholesterolemia, and that individuals with both high lipoprotein(a) concentrations and clinical familial hypercholesterolemia have the highest risk of myocardial infarction.


Clinical manifestation of Homozygous Familial Hypercholesterolemia, interdigital xanthoma
Source: labmedica

Rising Liquid Biopsy Tide Lifts Cancer Dx

Traditional Tissue Biopsies Are Not Providing the Type of Real-Time Monitoring Necessary for Effectively Catching Relapse

As molecular diagnostics for oncology shifts into clinical practice, efforts have not only focused on genotyping patient-specific tumors to initiate targeted therapies, but on early detection, availability, improved quality control, and refined workflow.

One major push, that exemplifies the concomitance of these trends, has been the rise of the less-invasive and more cost-effective liquid sampling for cancer diagnosis; sometimes called a liquid biopsy.


The FDA recently approved Hologic’s prostate cancer test, which improves upon the less sensitive
and less specific standard PSA tests via examination of the PCA3 gene in urine.
Source: genengnews
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