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Saturday, April 23, 2016

Wondering why your belly fat won't disappear?

You work hard to lose weight, but the pooch won't budge. Our friends at Shape share some reasons as to why this is happening.

You can work out like a champ, eat virtuously, and get sound sleep but still stay thick around the middle. Blame some newly discovered triggers that undermine your slim-down efforts by making you pack on the belly flab. Take note, and trim down.

Living on a Busy Street
Regular exposure to traffic noise makes you 29 percent more likely to have a bigger waistline, according to findings in Occupational & Environmental Medicine. Other research found that such noise may spike your cortisol, a hormone associated with ab fat. Three suggestions for you: Drown out the noise by playing soothing music (studies revealed that such tunes lower cortisol levels), muffle the clamor with a background- noise machine, or pop in noise-canceling earbuds when you need to focus.

Your Fizzy Drink Habit
Ironically, people who sip the no-cal stuff in an effort to cut calories are actually more likely to gain belly fat. Diet soda drinkers who averaged about a can and a half a day packed 3.2 inches onto their waistlines over the course of nine and a half years, while those drinking fizzy drinks gained less than an inch, a recent study at the University of Texas Health Science Center found. One reason is that artificial sweeteners prevent the brain from registering satiety, thus increasing cravings for sweets, so you end up eating more, says study author Helen Hazuda.


Reasons You Might Not Be Able to Lose Belly Fat
Source: Shutterstock 

Genetic variants influencing kidney disease progression

A new study suggests that patients with focal segmental glomerulosclerosis - a type of kidney disease - may have a more advanced form of the condition at diagnosis if they possess certain genetic variants, with this association being strongest among African Americans.

The researchers, including Dr. Jeffery Kopp of the National Institutes of Health, publish their findings in the Journal of the American Society of Nephrology.

Focal segmental glomerulosclerosis (FSGS) is scarring in kidney tissue that affects more than 5,000 people in the US every year. Symptoms of the condition include foamy urine (caused by excess protein), weight gain, swelling (caused by excess body fluids) and poor appetite.

According to the researchers, FSGS is known to be more common among African Americans; compared with European Americans, African Americans are four times more likely to develop the condition.

Previous research has indicated that African Americans are at higher risk of chronic kidney disease (CKD) due to variants in apolipoprotein L1 (APOL1) - a gene that makes a protein that forms a part of high-density lipoprotein (HDL), referred to as "good" cholesterol. Around 5 million African Americans possess such variants.


The researchers found that 72% of African American participants with FSGS - a form of kidney disease
- had variants in the APOL1 gene.

Unlocking the secret to healthy aging!

A new study may bring us closer to unlocking the secret to healthy aging, after uncovering an array of genetic variants among healthy, elderly individuals that may protect against Alzheimer's and heart disease.

The findings come from the ongoing "Wellderly" study, in which researchers have so far applied whole genome sequencing to the DNA of more than 1,400 healthy individuals from the US aged 80-105 years.

Launched in 2007, the study aims to pinpoint certain genetic variants that may contribute to lifelong health.

"This study is exciting because it is the first large one using genetic sequencing to focus on health," says Michael Snyder, PhD, chairman of the Department of Genetics at Stanford University in California, who was not involved with the research.

"Most of the world's scientists are studying disease, but what we really want to understand is what keeps us healthy. That is what the Wellderly study is all about."


Researchers have uncovered some of the secrets of healthy aging with their new gene study.

Hubble Sees a Star 'Inflating' a Giant Bubble

For the 26th birthday of NASA’s Hubble Space Telescope, astronomers are highlighting a Hubble image of an enormous bubble being blown into space by a super-hot, massive star. The Hubble image of the Bubble Nebula, or NGC 7635, was chosen to mark the 26th anniversary of the launch of Hubble into Earth orbit by the STS-31 space shuttle crew on April 24, 1990 “As Hubble makes its 26th revolution around our home star, the sun, we celebrate the event with a spectacular image of a dynamic and exciting interaction of a young star with its environment.

The view of the Bubble Nebula, crafted from WFC-3 images, reminds us that Hubble gives us a front row seat to the awe inspiring universe we live in,” said John Grunsfeld, Hubble astronaut and associate administrator of NASA’s Science Mission Directorate at NASA Headquarters, in Washington, D.C.

The Bubble Nebula is seven light-years across—about one-and-a-half times the distance from our sun to its nearest stellar neighbor, Alpha Centauri, and resides 7,100 light-years from Earth in the constellation Cassiopeia. The seething star forming this nebula is 45 times more massive than our sun. Gas on the star gets so hot that it escapes away into space as a “stellar wind” moving at over four million miles per hour. This outflow sweeps up the cold, interstellar gas in front of it, forming the outer edge of the bubble much like a snowplow piles up snow in front of it as it moves forward.

As the surface of the bubble's shell expands outward, it slams into dense regions of cold gas on one side of the bubble. This asymmetry makes the star appear dramatically off-center from the bubble, with its location in the 10 o’clock position in the Hubble view. Dense pillars of cool hydrogen gas laced with dust appear at the upper left of the picture, and more “fingers” can be seen nearly face-on, behind the translucent bubble. The gases heated to varying temperatures emit different colors: oxygen is hot enough to emit blue light in the bubble near the star, while the cooler pillars are yellow from the combined light of hydrogen and nitrogen.

The pillars are similar to the iconic columns in the “Pillars of Creation” Eagle Nebula. As seen with the structures in the Eagle Nebula, the Bubble Nebula pillars are being illuminated by the strong ultraviolet radiation from the brilliant star inside the bubble. The Bubble Nebula was discovered in 1787 by William Herschel, a prominent British astronomer. It is being formed by an O star, BD +60ยบ2522, an extremely bright, massive, and short-lived star that has lost most of its outer hydrogen and is now fusing helium into heavier elements. The star is about four million years old, and in 10 million to 20 million years, it will likely detonate as a supernova.

Hubble’s Wide Field Camera-3 imaged the nebula in visible light with unprecedented clarity in February 2016. The colors correspond to blue for oxygen, green for hydrogen, and red for nitrogen. This information will help astronomers understand the geometry and dynamics of this complex system. The Bubble Nebula is one of only a handful of astronomical objects that have been observed with several different instruments onboard Hubble. Hubble also imaged it with the Wide Field Planetary Camera (WFPC) in September 1992, and with Wide Field Planetary Camera-2 (WFPC2) in April 1999.

The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency. NASA's Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts Hubble science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy in Washington, D.C. Credit: NASA, ESA, and the Hubble Heritage Team (STScI/AURA) 

Video link: A really cool video



Source: the Bubble Nebula and the Hubble telescope

Friday, April 22, 2016

Discovery of new state of water molecule!

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of water molecules confined in hexagonal ultra-small channels - 5 angstrom across - of the mineral beryl. An angstrom is 1/10-billionth of a meter, and individual atoms are typically about 1 angstrom in diameter.

The discovery, made possible with experiments at ORNL's Spallation Neutron Source and the Rutherford Appleton Laboratory in the United Kingdom, demonstrates features of water under ultra confinement in rocks, soil and cell walls, which scientists predict will be of interest across many disciplines.


ORNL researchers discovered that water in beryl displays some unique and unexpected characteristics.
Source: Jeff Scovil

Reasons Why Your Body Needs Water Every Day

We all know that water is essential for life, but have you ever wondered why your body needs so much replenishing? 

As explained in the TedEd video link below, water is crucial for the body's everyday, biological functions. The majority of the human body is made up of water: We rely on it to lubricate our joints, regulate temperature and to care for the brain and spinal cord. Without enough water, we'd be dry, unfocused, unenergized and creaky.

On average, we lose two to three liters of water a day, through sweat, breath, urine and bowel movements. To compensate, we've got to rehydrate. While past guidance has suggested we drink approximately eight glasses a day, new recommendations say we should drink anywhere from 2 to 3.7 liters (8.4 to 15.6 cups) daily, depending on a person's sex, weight, health and environment.



Close-up of a woman drinking water from a bottle

Why Do Celebrity Deaths Feel So Personal?

Prince's untimely death Thursday at the age of 57 left fans shocked and in mourning. While many express their grief, others are surprised to experience a strong personal reaction: I didn’t know him, some have thought, so why am I this upset?

The truth is, there’s no rulebook when it comes to grief, explains psychologist David Kaplan, chief professional officer of the American Counseling Association. The emotion is so swallowing and vast that it’s hard to pinpoint why it manifests in the ways that it does. But just because we can’t explain grief doesn’t mean it’s invalidated, Kaplan says — and that especially goes for grieving a celebrity.

“We grow up with these people,” Kaplan told The Huffington Post. “We see their movies, we hear their music on a regular basis and we really get to know them. In a sense, they become a member of our family — especially the ones we really like — so when they die, it’s like an extended member of our family dies. It’s somebody we feel like we know.”

These deaths also feel so personal because they resonate with us on a deeper, psychological level. We may grieve celebrities because our dream was to emulate their career path or because a celebrity death can also remind us of our mortality, Kaplan notes.


Prince (Prince Rogers Nelson) 'The Artist Formerly Known as Prince', 'TAFKAP' Hop Farm Festival,
Paddock Wood, Kent, England 3rd July 2011 performing live on stage in concert gig singing playing…

HIV Patients Now Living Long Enough to Develop Alzheimer's

Findings upend previous beliefs about brain changes related to the AIDS-causing virus

The first case of Alzheimer's disease diagnosed in a person with HIV highlights the fact that long-time HIV survivors are starting to reach ages where their risk for Alzheimer's increases, researchers report.

The 71-year-old man was diagnosed after a medical scan revealed amyloid protein clumps in his brain. Until now, it was believed that HIV-related inflammation in the brain might prevent the formation of such clumps and thereby protect these people from Alzheimer's.

"This patient may be a sentinel case that disputes what we thought we knew about dementia in HIV-positive individuals," said study author Dr. R. Scott Turner. He is head of the Memory Disorders Program at Georgetown University Medical Center in Washington, D.C.

The case also suggests that some older people with HIV and dementia may be misdiagnosed with HIV-associated brain disorders, but actually have Alzheimer's disease. It's also possible that some older people with HIV have both HIV-associated brain disorders and Alzheimer's, according to Turner.

"Chronic HIV infection and amyloid deposition with aging may represent a 'double-hit' to the brain that results in progressive dementia," he said in a university news release.


Biomarker Predicts Risk of Preterm Birth Earlier

A standard biomarker test offered earlier in pregnancy could potentially help doctors to better identify women at risk of giving birth prematurely, thus enabling health services to focus treatments on women at highest risk.

A number of factors are used to determine if a woman is at risk of giving birth prematurely, including a history of preterm births or late miscarriages. Two further factors which clinicians normally consider are the length of cervix and levels of a biomarker found in vaginal fluid known as fetal fibronectin.

Scientists at King's College London (London, UK) compared measurements of a new fetal fibronectin test in the cervicovaginal fluid of women at 18 to 21 weeks of gestation with measurements made at 22 to 27 weeks of gestation, to see which time period offered the best prediction of spontaneous preterm birth. They also explored whether using a low (10 ng/mL) and high (200 ng/mL) threshold would more accurately classify a women's risk of giving birth prematurely.


Fetal fibronectin is a “glue-like” protein that holds the developing baby in the womb
Source: Hologic Inc.

Thursday, April 21, 2016

Fifty Biotech and Biopharma Recruiters in the Lists.

Who They Know Can Help You Land a Job in the Industry

In Deloitte’s “2016 U.S. Life Sciences Industry Outlook” released in January, Greg Reh, the firm’s U.S. and Global Life Sciences sector leader, offered a somewhat encouraging assessment of employment prospects this year: “Despite current economic, political, technological, and social challenges, life sciences companies worldwide should see enough long-term growth opportunities to feel cautiously optimistic about 2016.”

Three such opportunities were identified by recruiting firm Smith Hanley Associates earlier this year: One was candidate movement to smaller biopharmas, which the firm said leads to higher base salaries as companies scramble to offset the loss of long-term incentives given by big pharma. Mergers and acquisitions create jobs for candidates willing to relocate, whereas the growth of big data adds positions for in-house data scientists but also results in project outsourcing to vendors that creates new markets and innovations, Smith Hanley added.

All those trends should mean more work for biopharma recruiters, who match employers with job candidates in significant portions of the industry.


The workload of recruiters should increase this year since biotech and other life sciences employers
worldwide “should see enough long-term growth opportunities to feel cautiously optimistic about
2016,” according to Deloitte Consulting.
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