Biomedical Laboratory Science

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Tuesday, June 7, 2016

A Scientific Approach to Scientific Writing

This guide provides a framework, starting from simple statements, for writing papers for submission to peer-reviewed journals. It also describes how to address referees’ comments, approaches for composing other types of scientific communications, and key linguistic aspects of scientific writing.

Essential Steps Before Writing a Paper
Having completed a study and acquired all the data required to present it, you are ready to begin preparing a paper. However, before beginning to write, you have to take several critical preliminary steps: Your notes must be gathered, a suitable place for writing must be found, a selective literature review may be helpful, a target journal must be identified, linguistic limitations must be recognized, the study must be defined and delimited, and the information must be arranged. Failure to take these steps will make writing more difficult and seriously compromise the chances of publication. Therefore, this chapter outlines what needs to be done in each of these steps.



Download here: 1. www.victoria.ac.nz
                           2. books.google.com.np

Sunday, June 5, 2016

MCQ 4. A 60 year old man is diagnosed with a MALToma. This is attributed to a translocation involving MALT1 and a gene.


MCQ 4. A 60 year old man is diagnosed with a MALToma. This is attributed to a translocation involving MALT1 and a gene.

Which is this gene?
a. BCL1
b. BCL2
c. BCL6
d. BCL10
e. BCL12

Correct answer: Click here

MCQ 3: What is the normal average life span of red blood cells in our body?


3. What is the normal average life span of red blood cells in our body?
a. 10 days
b. 120 days
c. 240 days
d. 360 days

Correct answer link: Click here

Saturday, June 4, 2016

Cholesterol: Types, Treatments, and Lifestyle Changes



Source: Healthline Networks

What Do You Want to Know About High Cholesterol?

Cholesterol is a substance that your liver produces naturally. It’s vital for the formation of cell membranes, vitamin D, and certain hormones.

Cholesterol is a waxy, fat-like substance. It doesn’t dissolve in water and therefore can't travel through the blood by itself. Lipoproteins are other particles formed in the liver that help transport cholesterol through the bloodstream. There are several major forms of lipoproteins that are important to your health.


Thursday, June 2, 2016

Medical Video: How to Perform Endotracheal Intubation.

Prepare for emergency and watch this fascinating animated video to learn how to perform neonatal endotracheal incubation.


Source: MedicalVideos

Monday, May 30, 2016

Medical Video: How does insulin work in the body

Take a trip inside the body in this fascinating animated video to find out how insulin works in the body.



Source: MedicalVideos

New Gene Associated With Familial High Cholesterol

The gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol has been revealed. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people.

The reason why lipoprotein(a) concentrations are raised in individuals with clinical familial hypercholesterolemia is unclear. The hypotheses that high lipoprotein(a) cholesterol and LPA risk genotypes are a possible cause of clinical familial hypercholesterolemia, and that individuals with both high lipoprotein(a) concentrations and clinical familial hypercholesterolemia have the highest risk of myocardial infarction.


Clinical manifestation of Homozygous Familial Hypercholesterolemia, interdigital xanthoma
Source: labmedica

Rising Liquid Biopsy Tide Lifts Cancer Dx

Traditional Tissue Biopsies Are Not Providing the Type of Real-Time Monitoring Necessary for Effectively Catching Relapse

As molecular diagnostics for oncology shifts into clinical practice, efforts have not only focused on genotyping patient-specific tumors to initiate targeted therapies, but on early detection, availability, improved quality control, and refined workflow.

One major push, that exemplifies the concomitance of these trends, has been the rise of the less-invasive and more cost-effective liquid sampling for cancer diagnosis; sometimes called a liquid biopsy.


The FDA recently approved Hologic’s prostate cancer test, which improves upon the less sensitive
and less specific standard PSA tests via examination of the PCA3 gene in urine.
Source: genengnews

Sunday, May 29, 2016

RNAi Is Working on Tactics to Avoid siRNA Degradation and Improve Targeting and Delivery

Initially observed in plants and the nematode Caenorhabditis elegans, and subsequently in all major eukaryotic species, RNA interference (RNAi) has been recognized as a post-translational mechanism for the silencing of specific genes. RNAi is instigated by double-stranded RNA (dsRNA) molecules, and it exploits the base sequences of dsRNA, or rather the base sequences of the molecules derived from dsRNA, to silence genes in a sequence-specific manner.

RNAi evolved as a way to protect host genomes from parasitic nucleotide sequences, such as those arising from viral infections. But RNAi is not just a natural mechanism. It is also a contrivance, a research tool or, potentially, a therapeutic modality. The RNAi pathway provides a new framework to artificially introduce dsRNA into organisms to silence specific genes based on sequence complementarity.


Researchers from The University of Texas Medical Branch at Galveston have developed a post-exposure
treatment that is effective against the Makona strain of Ebola. The treatment, which has been tested
in nonhuman primates, is being evaluated for use in infected patients in Sierra Leone. It uses a
sequence-specific short interfering RNAs (siRNAs) to target and interfere with the Ebola virus.
The siRNAs are encapsulated in lipid nanoparticles to potentiate cellular delivery.
Source: genengnews
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