DNA: Past to Present 2017

National DNA Day is not only a celebration of the structure and sequence of the double-helix, but also the tireless commitment of researchers to understand the complexities of our genetic blueprint. As we revel in all things DNA, the GEN editorial staff has assembled a brief video timeline highlighting significant dates in DNA discovery.

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Source: GenEngNews

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Research Antibody Reproducibility

It’s All About Validation

The reproducibility of scientific studies has become a major issue, leading to a lack of trust in scientific results from the academic and pharmaceutical research communities. While issues around reproducibility have been discussed for years, calls for action have been infrequent and half-hearted. Beginning in about 2012, a number of articles, letters, and editorials started appearing in Nature, Science and other publications, with some going so far as to call this a “reproducibility crisis.”

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The lack of consistent research on antibody validation has contributed to the scientific reproducibility
crisis.

Source: genengnews

Islet transplantation, blood sugar and type 1 diabetes

New clinical trial results show that transplantation of pancreatic islets--cell clusters that contain insulin-producing cells--prevents severe, potentially life-threatening drops in blood sugar in people with type 1 diabetes. Researchers found that the treatment was effective for people who experienced episodes of severe hypoglycemia--low blood sugar levels that can lead to seizures, loss of consciousness and death--despite receiving expert care.

The Phase 3 trial was funded by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), both part of the National Institutes of Health, and was conducted by the NIH-sponsored Clinical Islet Transplantation (CIT) Consortium. The investigators designed the study in consultation with the U.S. Food and Drug Administration to enable potential future licensure of the manufacture of purified human pancreatic islets. The results appear online today in Diabetes Care.

"The findings suggest that for people who continue to have life-altering severe hypoglycemia despite optimal medical management, islet transplantation offers a potentially lifesaving treatment that in the majority of cases eliminates severe hypoglycemic events while conferring excellent control of blood sugar," said NIAID Director Anthony S. Fauci, M.D.

Read more: Islet transplantation, blood sugar and type 1 diabetes

Transplantation of pancreatic islets--cell clusters that contain insulin-producing cells--prevents severe,
potentially life-threatening drops in blood sugar in people with type 1 diabetes, according to new research

Source: ibreakstock/Fotolia

Harvard scientists are stunned by superhuman abilities of Himalayan monks.

Most of us have a fairly good idea that brains of Buddhist monks function far beyond most humans’ capabilities and that the monks can actually rewire their brains. While there is no question that Buddhist monks possess superhuman powers, how they do some really incredible out-of-this-world kind of stuff continues to fascinate and show scientists what we – ‘normal human beings’ – can all do.

Professor Herbert Benson and his team of researchers from the Harvard School Of Medicine went to remote monasteries in the Himalayan mountains in the 1980′s to discover, decode, and document the subtle ways through which the monks manipulate their bodies – like raising the temperatures of their fingers and toes by as much as 17 degrees, and lowering their body’s metabolic rate by up to 64% – using a stress reduction yoga technique called ‘g Tum-mo’.

The Harvard research team also recorded monks drying cold, wet sheets with body heat. They also documented monks spending a winter night – when temperatures reached zero degrees F – on a rocky ledge 15,000 feet high in the Himalayas — wearing only woolen or cotton shawls. These remarkable feats, the Harvard research team observed, were achieved by intense daily meditations, guided exercises and spiritual conditioning.

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Source: anonhq

Scientists develop supersensitive biosensor for cancer

A team of physicists and engineers at Case Western Reserve University in Cleveland, OH, has created an optical biosensor for cancer detection using nanostructured metamaterials that are 1 million times more sensitive than previous versions, pointing the way toward an effective early detection system for cancer and other illnesses.

The device, which is small enough to fit in the palm of a hand, has been developed to provide oncologists with a way to detect a single molecule of an enzyme produced by circulatingcancer cells.

Such detection could allow doctors to diagnose patients with certain cancers far earlier than possible today, monitor treatment and resistance, and more.

The research, published online in the journalNature Materials, describes how the nanosensor acts like a biological sieve, isolating a small protein molecule weighing less than 800 quadrillionths of a nanogram from an extremely dilute solution.

The researchers believe the sensing technology will also be useful in diagnosing and monitoring other diseases.

"The prognosis of many cancers depends on the stage of the cancer at diagnosis," says Giuseppe "Pino" Strangi, professor of physics at Case Western Reserve and leader of the research.

Read more: Scientists develop supersensitive biosensor for cancer

The researchers used nanostructured metamaterials 1 million times more sensitive
than previous versions, enabling an early detection system for cancer.

Source: medicalnewstoday