Dopamine receptors in the cortex orient the brain toward the task at hand.
A new study reveals how dopamine contributes to working memory. Using simultaneous positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), scientists have shown that the density of cortical dopamine D1 receptors in healthy individuals is related to a decoupling of the frontoparietal and default networks. The findings, reported by researchers from Massachusetts General Hospital (MGH) in Boston and colleagues today (June 3) in Science Advances, may offer clues to how dopamine signaling becomes disrupted in schizophrenia and other psychiatric disorders.
“The end game is trying to relate [dopamine signaling] back to schizophrenia and other disorders with working memory impairment,” study coauthor Joshua Roffman of MGH and Harvard University told The Scientist.
Read more: How Dopamine Tunes Working Memory
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PET-MRI of dopamine receptor density and network function
JOSHUA ROFFMAN MD, MMSC
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Source: theScientist
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