Biomedical Laboratory Science

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Tuesday, April 5, 2016

Disposing HIV from human immune cells with new gene-editing technique.

They've managed to shut down HIV replication permanently.

Using the much-touted CRISPR/Cas9 gene editing method, scientists have demonstrated how they can edit HIV out of human immune cell DNA, and in doing so, can prevent the reinfection of unedited cells too.

If you haven’t heard of the CRISPR/Cas9 gene-editing technique before, get ready to hear a whole lot more about it in 2016, because it’s set to revolutionise how we investigate and treat the root causes of genetic disease. It allows scientists to narrow in on a specific gene, and cut-and-paste parts of the DNA to change its function.

CRISPR/Cas9 is what researchers in the UK have recently gotten approval to use on human embryos so they can figure out how to improve IVF success rates and reduce miscarriages, and it’s what Chinese scientists were caught using in 2015to tweak human embryos on the down-low.

Earlier this year, scientists started using CRISPR/Cas9 to successfully treat a genetic disease - Duchenne muscular dystrophy - in living mammals for the first time, and now it’s showing real potential as a possible treatment for HIV in the future.

Read more: Disposing HIV from human immune cells with new gene-editing technique.

An HIV-infected T-cell.
Source: NIAID/Flickr

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