Biomedical Laboratory Science

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Thursday, April 7, 2016

Gut microbes regulate nerve fibre insulation.

Far from being silent partners that merely help to digest food, the bacteria in your gut may also be exerting subtle influences on your thoughts, moods, and behaviour. And according to a new study from researchers at University College Cork, your gut microbes might affect the structure and function of the brain in a more direct way, by regulating myelination, the process by which nerve fibres are insulated so that they can conduct impulses properly.

The surprising new findings, published today in the journal Translational Psychiatry, provide what is perhaps the strongest evidence yet that gut bacteria can have a direct physical effect on the brain, and suggest that it may one day be possible to treat debilitating demyelinating diseases such as multiple sclerosis, and even psychiatric disorders, by altering the composition of the gut’s microbial menagerie in some way or another.

Gut microbe research has exploded in the past 10 years, and in that time, it has become increasingly clear that there is a two-way line of communication betweengut bacteria and the brain. The human gut microbiome seems to play important roles in health and disease, and alterations in its composition have been implicated in a wide range of neurological and psychiatric conditions, including autism, chronic pain, depression, and Parkinson’s Disease, although the links still remain somewhat tenuous.

Read more: Gut microbes regulate nerve fibre insulation.

Scanning electron micrograph showing E. coli bacteria.
Source: Wikimedia Commons

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