Biomedical Laboratory Science

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Showing posts with label Disorders. Show all posts
Showing posts with label Disorders. Show all posts

Sunday, June 10, 2018

Serum Iron Test: High, Low, and Normal Ranges !

Having too much or too little iron in the blood can cause serious health problems.
If a doctor suspects that a person does not have a healthy amount of iron in their blood, they may order a serum iron test.


In this article, learn more about the uses of a serum iron test. We also explain the normal ranges of iron in the blood and the treatment options for people whose iron levels are too high or too low.

Friday, September 2, 2016

What is the Function of the Hypothalamus?

The hypothalamus is a small area in the center of the brain that has many jobs. It plays an important role in hormone production and helps to stimulate many important processes in the body.

When the hypothalamus is not working properly, it can cause problems in the body leading to many disorders. Though diseases of the hypothalamus are uncommon, it is important to keep it healthy to keep the risk low.

Contents of this article:
  1. What is the hypothalamus?
  2. Hypothalamus disorders
  3. Diet tips for hypothalamus health

The hypothalamus plays a huge role in both the endocrine and nervous systems. Head injuries impacting
the hypothalamus are the most common cause of hypothalamic disease. Diets high in saturated fats can
influence and alter the function of the hypothalamus.

Saturday, August 13, 2016

Thyroid Hormone Receptors and Resistance to Thyroid Hormone Disorders

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal or elevated levels of TSH and goitre.

Mechanistic insights about the contributions of THRβ to various processes, including colour vision, development of the cochlea and the cerebellum, and normal functioning of the adult liver and heart, have been obtained by either introducing human THRB mutations into mice or by deletion of the mouse Thrb gene. The introduction of the same mutations that mimic human THRβ alterations into the mouse Thra and Thrb genes resulted in distinct phenotypes, which suggests that THRA and THRB might have non-overlapping functions in human physiology.

These studies also suggested that THRA mutations might not be lethal. Seven patients with mutations in THRα have since been described. These patients have RTHα and presented with major abnormalities in growth and gastrointestinal function. The hypothalamic–pituitary–thyroid axis in these individuals is minimally affected, which suggests that the central T3 feedback loop is not impaired in patients with RTHα, in stark contrast to patients with RTHβ.


Overview of tissues and homeostatic functions affected in RTHα and RTHβ.

Wednesday, July 6, 2016

Top Signs There’s Something Wrong With Your Thyroid

One of the most important parts of our bodies is also one of the smallest ones. The thyroid, butterfly-shaped gland on the front of the neck below the Adam’s apple, releases hormones that have a huge impact on metabolism, among other processes.

Thyroid disorders can have a significant impact on your attitude and temperament. Hypothyroidism tends to make people feel depressed. This is due to the fact that too little thyroid hormones decreases the “happiness” hormone, serotonin, in the brain.



Sunday, May 1, 2016

Disorders that can affect the placenta during pregnancy

The placenta and its health are vital to the health of a woman's pregnancy and fetal development. This organ provides oxygen, nutrients, and filters fetal waste during pregnancy.

It also plays an important role in hormone production and protects the fetus from bacteria and infections.

The blood-rich placenta is joined to the uterine wall and connects to the baby by way of the umbilical cord.

Most often the placenta attaches itself to the top or side of the uterine wall. At times, however, it may grow or attach to the uterus in a way that can cause health problems.


The risk of placental disorders is affected by ethnicity, lifestyle and medical history.
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