Differences between Type 1 and Type 2 Diabetes.

Diabetes, or diabetes mellitus (DM), is a metabolic disorder in which the body cannot properly store and use sugar.

It affects the body's ability to use glucose, a type of sugar found in the blood, as fuel. This happens because the body does not produce enough insulin, or the cells do not correctly respond to insulin to use glucose as energy.

Insulin is a type of hormone produced by the pancreas to regulate how blood sugar becomes energy. An imbalance of insulin or resistance to insulin causes diabetes.

Diabetes is linked to a higher risk of cardiovascular disease, kidney disease, vision loss, neurological conditions, and damage to blood vessels and organs.

There is type 1, type 2, and gestational diabetes. They have different causes and risk factors, and different lines of treatment.

This article will compare the similarities and differences of types 1 and 2 diabetes.

People with type 1 diabetes will require supplemental insulin on an

ongoing basis. People with type 2 will likely only need this for the later

stages of the condition. A healthcare specialist will be able to test

a patient for diabetes, even if type 2 diabetes shows no symptoms.

Read more: Differences between Type 1 and Type 2 Diabetes.

Source: MedicalNewsToday

Thyroid Hormone Receptors and Resistance to Thyroid Hormone Disorders

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal or elevated levels of TSH and goitre.

Mechanistic insights about the contributions of THRβ to various processes, including colour vision, development of the cochlea and the cerebellum, and normal functioning of the adult liver and heart, have been obtained by either introducing human THRB mutations into mice or by deletion of the mouse Thrb gene. The introduction of the same mutations that mimic human THRβ alterations into the mouse Thra and Thrb genes resulted in distinct phenotypes, which suggests that THRA and THRB might have non-overlapping functions in human physiology.

These studies also suggested that THRA mutations might not be lethal. Seven patients with mutations in THRα have since been described. These patients have RTHα and presented with major abnormalities in growth and gastrointestinal function. The hypothalamic–pituitary–thyroid axis in these individuals is minimally affected, which suggests that the central T3 feedback loop is not impaired in patients with RTHα, in stark contrast to patients with RTHβ.

Read more: Thyroid Hormone Receptors and Resistance to Thyroid Hormone Disorders

Overview of tissues and homeostatic functions affected in RTHα and RTHβ.

Source: NatureReviewsEndocrinology

Literature Review: Targeting Mutant Kinases

Small-Molecule Kinase Inhibitors Have Typically Been Designed To Inhibit Wild-Type Kinases Rather Than the Mutant Forms

Kinases have been the target of extensive research to identify drugs to treat a variety of diseases in which the wild-type kinase or a mutant kinase plays a crucial role. Kinase mutations frequently lead to an activated state where the kinase is always active and no longer tightly regulated. Considering resistance mutations are also important for kinase inhibitors. A frequent escape route is a mutation to the gatekeeper amino acid that blocks inhibitor binding. A variety of large screening panels have been developed that range from binding assays to enzyme assays, each with their unique pros and cons.

Read more: Literature Review: Targeting Mutant Kinases

A variety of large screening panels have been developed that range from binding assays

to enzyme assays, each with their unique pros and cons. [nicolas_/Getty]

Source: genengnews

Overcoming the Fear of Injections for Diabetes

Do you have an objection to injections? If you have type 2 diabetes, you may be afraid you’ll eventually need to give yourself insulin injections, or maybe your doctor has mentioned non-insulin injections might be in your future.

Treating diabetes with injections does not mean you have failed or did not follow your doctor’s instructions. Many diabetics will need insulin shots over time, and non-insulin injections are just a newer form of diabetes medication. However, you do need to overcome your fear and resistance if you want to get your diabetes under control. In order to do this, it’s important to determine the root of your anxiety, and identifying the problem can help you find solutions.

Get the Facts

While there have been attempts at developing an inhaled insulin, injections are currently the most common form of delivery with the technology available today.

Read more: Overcoming the Fear of Injections for Diabetes

Source: msn/health/medical

Measles: Causes, Symptoms and Treatments

Measles, also known as Rubeola or morbilli, is a highly infectious illness caused by a virus - a viral infection caused by the rubeola virus.

Measles is an endemic disease; meaning it is continually present in a community and many people develop resistance. If measles enters an area where the people have never been exposed the result can be devastating.

A measles outbreak in 1592 in the island of Cuba killed approximately two-thirds of the native population who had previously survived smallpox. A couple of years later half the indigenous population of Honduras died.

Read more: Measles: Causes, Symptoms and Treatments

Measles symptoms can often include a reddish-brown spotty rash.

Source: medicalnewstoday