Test That Differentiates Between Bacterial, Viral Infections in Development

An international team of scientists - led by researchers at Imperial College London - has discovered two genes that are switched on when a child has a bacterial infection. This revelation could allow the team to develop a rapid test for doctors' surgeries and hospitals to identify infections such as meningitis, and assist with the growing threat of antibiotic resistance.

The study, published in JAMA, found that the two genes, called IFI44L and FAM89A, only shifted to an "on" state when a bacterial infection was present. This knowledge could enable doctors to distinguish between bacterial and viral infections, and identify early cases of severe infections that could be deadly.

While viral infections are more common than bacterial infections, bacterial infections are often more serious.

Meningitis, septicemia, and pneumonia all occur as a result of a bacterial infection. Differentiating between these potentially life-threatening conditions and viruses can allow health providers to provide quicker, more accurate treatments.

Read more: Test That Differentiates Between Bacterial, Viral Infections in Development

Doctors usually have to send samples away to diagnose bacterial or viral infections. The new test
could provide a rapid way for doctors to test patients immediately.

Source: medicalnewstoday

Antibiotic Resistance Raising the Specter of 'Untreatable Gonorrhea'

A new federal health surveillance study says gonorrhea is becoming resistant to azithromycin - one of the duo of antibiotics recommended for treating the sexually transmitted disease in the United States.

The study, from the Centers for Disease Control and Prevention (CDC), is published in the agency's Morbidity and Mortality Weekly Report (MMWR).

Gonorrhea is a sexually transmitted disease (STD) caused by a bacterium called Neisseria gonorrhoeae that infects the genitals, rectum, and throat.

Gonorrhea occurs in both men and women, and is one of the most common STDs in the U.S. It is especially common among young people of 15-24 years of age.

Read more: Antibiotic Resistance Raising the Specter of 'Untreatable Gonorrhea'

The CDC say the growing threat of untreatable gonorrhea, together with rising rates of disease,
means preventing new infections is more important than ever.

Source: medicalnewstoday

H. Pylori: Know the Facts

Helicobacter pylori, commonly called H. pylori, is a type of bacteria that can infect the stomach and small bowel. It was discovered in 1982 by two Australian researchers who found that it causes peptic ulcer disease.

Peptic ulcers are open sores in the lining of the stomach or the upper part of the small intestine. Peptic ulcers are often called "ulcers" or "stomach ulcers."

For years, medical experts believed that peptic ulcers were caused by stress or certain foods. After the discovery of H. pylori, however, this belief was put to rest. A study in Digestive and Liver Disease suggests that 60 to nearly 100 percent of peptic ulcers are associated with H. pylori.

Read more: H. Pylori: Know the Facts

H. pylori bacteria attack the protective lining of the stomach, causing ulcer, that can be diagnosed
with an endoscopy.

Source: medicalnewstoday

The superbug that doctors have been dreading just reached the U.S.

For the first time, researchers have found a person in the United States carrying bacteria resistant to antibiotics of last resort, an alarming development that the top U.S. public health official says could mean “the end of the road” for antibiotics.

The antibiotic-resistant strain was found last month in the urine of a 49-year-old Pennsylvania woman. Defense Department researchers determined that she carried a strain of E. coli resistant to the antibiotic colistin, according to a study published Thursday in Antimicrobial Agents and Chemotherapy, a publication of the American Society for Microbiology. The authors wrote that the discovery “heralds the emergence of a truly pan-drug resistant bacteria.”

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Source: washingtonpost

Not unexpectedly, a new drug-resistant ‘superbug’ pops up in the United States

For years, public health experts have warned us that deadly bacteria are developing resistance to all our available antibiotics. This week, researchers reported the first known U.S. case of an Escherichia coli infection resistant to colistin, a harsh drug seen as a last resort to knock out stubborn infections. The finding, described in the American Society for Microbiology journal Antimicrobial Agents and Chemotherapy, is no big surprise to researchers tracking the rise of resistant bacteria. The resistance gene, known as mcr-1, was discovered in E. coli in China last year, and has since cropped up in Europe.

As the United States crosses the same ominous milestone, research to understand resistance and develop new drugs is surging ahead. As Science reported earlier this month, evolutionary biologists have recently revisited old dogma about how best to prescribe antibiotics—revealing that trusted strategies such as using a high dose may not actually help prevent resistance.

Read more: Not unexpectedly, a new drug-resistant ‘superbug’ pops up in the United States

E. coli bacteria growing in a dish.

Source: sciencemag

'Millions will die' from antimicrobial resistance unless we act now

From helping humans live longer and hacking our performance, to repairing the body and understanding the brain, WIRED Health will hear from the innovators transforming this critical sector.

Ten million people around the world will die each year by 2050 if more is not done to tackle the growing threat of antimicrobial resistance, Jim O'Neill, commercial secretary to the treasury, has said.

Speaking at WIRED Health, O'Neill said the rise in resistance needs to be "embraced by policy makers around the world".

If it isn't then the number of people dying from antimicrobial resistance (AMR) will increase dramatically.

Read more: 'Millions will die' from antimicrobial resistance unless we act now

Staphylococcus Aureus

Source: Getty Images / BSIP

Antibiotics not promote resistance through gene conjugation.

The exponential rise of antibiotic drug resistance is a considerable threat to global public health. Researchers are continually searching for the underlying mechanisms that promote this resistant phenotype. Some evidence exists to suggest that antibiotic use encourages the spread of bacterial resistance through genetic swapping. However, new research suggests that these examples are outliers and not indicative of the majority of bacterial populations.

Researchers at Duke University suggest that differential birth and death rates of microbes and not DNA donation are to blame. The results have implications for designing antibiotic protocols to avoid the spread of antibacterial resistance. 

"The entire field knows there's a huge problem of overusing antibiotics," noted senior study author Lingchong You, Ph.D., associate professor of engineering at Duke University. "It is incredibly tempting to assume that antibiotics are promoting the spread of resistance by increasing the rate at which bacteria share resistant genes with each other, but our research shows they often aren't."

Investigators have known for decades that bacteria can swap genetic elements through a process called conjugation, which allows helpful genes to spread quickly between individuals and even between species. Because the number of resistant bacteria rises when antibiotics fail to kill them, many researchers have assumed that the drugs increased the amount of genetic swapping taking place. The Duke researchers, however, hypothesized that the antibiotics were killing off the two "parent" lineages and allowing a newly resistant strain to thrive instead.

Read more: Antibiotics not promote resistance through gene conjugation.

Source: biologyexams4u