Young women with irregular menstrual periods may be at higher risk of developing—and dying from—ovarian cancer later in life, researchers found in a 50-year study of California women. The new research provides the first evidence linking abnormally long cycles or missed periods to higher ovarian cancer risk. It also challenges a longstanding hypothesis that such risk rises progressively with a woman’s total number of ovulations.
Having fewer ovulatory cycles is widely viewed as a protective factor against ovarian cancer. It’s the reason that hormonal birth control pills, pregnancy, and tubal ligations—which stop ovulation—have been thought to reduce risk for that disease. “This study is certainly curious, because it contradicts what we thought we knew about ovarian cancer and incessant ovulation,” says Mitchell Maiman, an OB/GYN at Staten Island University Hospital in New York.
Although ovarian cancer accounts for just 3% of all cancers in women, it’s the leading cause of gynecological cancer deaths. Less than half of all women diagnosed with ovarian cancer survive more than 5 years. Early symptoms, including abdominal discomfort and bloating, often go unnoticed or are misdiagnosed as irritable bowel syndrome. Because there are no routine screening tests and few markers to identify groups with increased risk of ovarian cancers, most cases are found when they are beyond the point of curing. Age is one risk factor—more than half of all ovarian cancers are diagnosed in women over the age of 63. Heredity is another—10% to 15% of women diagnosed with ovarian cancer have one or more known genetic risk factors.
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| Ovarian cancer is the fifth leading cause of cancer death among women |
Source: SciePro/Science Source
