Biochemistry Lecture Notes - Uremia: Background, Pathophysiology, Etiology

Background

Uremia is a clinical syndrome associated with fluid, electrolyte, and hormone imbalances and metabolic abnormalities, which develop in parallel with deterioration of renal function. The term uremia, which literally means urine in the blood, was first used by Piorry to describe the clinical condition associated with renal failure.

Uremia more commonly develops with chronic kidney disease (CKD), especially the later stages, of CKD, but it also may occur with acute kidney injury (AKI) if loss of renal function is rapid. As yet, no single uremic toxin has been identified that accounts for all of the clinical manifestations of uremia. A number of toxins, such as parathyroid hormone (PTH), beta2 microglobulin, polyamines, advanced glycosylation end products, and other middle molecules, are thought to contribute to the clinical syndrome.

Read more: Biochemistry Lecture Notes - Uremia: Background, Pathophysiology, Etiology

Source: Medscape

Biochemistry Lecture Notes - Azotemia: Background, Pathophysiology, Etiology

Background

Azotemia is an elevation of blood urea nitrogen (BUN) and serum creatinine levels. The reference range for BUN is 8-20 mg/dL, and the normal range for serum creatinine is 0.7-1.4 mg/dL.

Each human kidney contains approximately 1 million functional units known as nephrons, which are primarily involved in urine formation. Urine formation ensures that the body eliminates the final products of metabolic activities and excess water in an attempt to maintain a constant internal environment (homeostasis). Urine formation by each nephron involves 3 main processes, as follows: 

• Filtration at the glomerular level 
• Selective reabsorption from the filtrate passing along the renal tubules 
• Secretion by the cells of the tubules into this filtrate 

Perturbation of any of these processes impairs the kidney’s excretory function, resulting in azotemia.

Read more: Biochemistry Lecture Notes - Azotemia: Background, Pathophysiology, Etiology.

Source: Medscape

Enlarged Prostate: Molecular Mechanism Clue May Explain Link To Inflammation

A new study reveals an important molecular clue about how inflammation may lead to prostate enlargement or benign prostatic hyperplasia. The researchers believe their discovery may also lead to ways of overcoming resistance to androgen-targeted treatment for the condition.

Enlarged prostate or benign prostatic hyperplasia (BPH) is a common condition in older men where the prostate gland is enlarged and not cancerous.

As the prostate gland enlarges, it presses against and pinches the urethra, the tube that allows urine to leave the bladder. Also, the bladder wall gradually thickens and the bladder may get weaker and lose the ability to empty completely.

Read more: Enlarged Prostate: Molecular Mechanism Clue May Explain Link To Inflammation

Enlarged prostate or benign prostatic hyperplasia (BPH) is a common condition in older men.

Source: medicalnewstoday

Chronic Kidney Disease

WHAT IS CHRONIC KIDNEY DISEASE?

The kidneys function as blood filters that drain waste products while retaining other valuable blood contents like proteins. If these filters are damaged, they initially may become “leaky,” and substances like proteins can seep from blood into urine. At later stages, these filters slowly shut down and lose their ability to filter. When kidney impairment lasts for more than 3 months, it is called chronic kidney disease. This process ultimately results in decreased urine production and kidney failure, with buildup of waste products in the blood and body tissues. One common reason for kidney failure in the United States is diabetes.

Sometimes chronic kidney disease is accompanied by high blood pressure, which not only can be caused by kidney damage but also further accelerates kidney injury and is a major reason for the negative effects of chronic kidney disease on other organs, including increased risk of heart disease and stroke, collection of excess body fluids, anemia, weakening of bones, and impairment of the way the body eliminates medications.

Read more: Chronic Kidney Disease

It is estimated that 1 in 10 US adults has chronic kidney disease, and many who have
he disease are not aware of it.

Source: jamanetwork

All You Need to Know About Nephritis

To understand kidney problems such as nephritis, it's helpful to start with some background on what the kidneys are, and what they do.

The kidneys are two bean-shaped, fist-sized organs found just under the ribs on the left and right sides of the spine. They remove impurities and extra water from the blood, filtering 120-150 quarts of blood a day, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

Each kidney consists of thousands of structures called nephrons, where the actual blood filtering takes place. In the nephron, a two-step cleaning process separates what the body needs to keep from what it can get rid of.

A filter called the glomerulus catches blood cells and protein, sending water and waste to a second filter, called a tubule. The tubule captures minerals. After that, what remains leaves the body as urine.

Read more: All You Need to Know About Nephritis

Nephritis can lead to kidney failure if not treated. There are various ways of preventing kidney damage
if someone has symptoms of nephritis. Monitoring blood pressure is important if kidney problems
develop.

Source: medicalnewstoday