What is a free PSA test and what is it for?

Free PSA Test

"The free prostate-specific antigen test, known as the free PSA test, is used to help detect signs of prostate cancer. The test measures the level of unbound prostate-specific antigen in the blood, which can help doctors to diagnose issues like inflammation of the prostate or cancer."

Free PSA tests are often used alongside other PSA tests to confirm a diagnosis or test results. Free PSA tests can also be used instead of a biopsy if the doctor suspects prostate cancer, but a biopsy may still be needed.

This article examines when a free PSA test is used, how it differs from a total PSA test, and what the results mean.

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Best Vitamins for Gastritis !

Gastritis is a condition where the inner lining of the stomach gets inflamed. It is often caused by consumption of excessive alcohol and even due to usage of anti-inflammatory drugs. It is mainly caused by the bacterial infections and several autoimmune disorders can lead to gastritis.

The symptoms of gastritis are indigestion, abdominal pain, nausea, vomiting and heartburn. Taking a multivitamin supplement is highly beneficial for those people suffering with gastritis. By eating a balanced diet and reducing stress, one can treat gastritis. Vitamins and minerals which function as antioxidant are best remedies to improve the digestive health.

Essential Vitamins For Gastritis

1. Vitamin C

Vitamin C is an essential nutrient for the functioning of several metabolic reactions in animals and plants. Since it cannot be produced in the body, vitamin C must be taken from foods. Vitamin C deficiency can cause scurvy in humans.

This vitamin helps the body to absorb calcium and iron salts in the body. And they help to aggravate the digestive process and can reduce the irritation in the inner lining of the stomach. People who take vitamin C can control and cure gastritis. Vitamin C is present in a variety of foods and some of them are oranges, guavas, green peppers, parsley, broccoli and papayas.

2. Vitamin A

Vitamin A plays an important role in many functions that take place in our body. It also functions as retinoic acid, which is an essential hormone required for growth of epithelial cells. Vitamin A is required for various intrinsic processes.

It helps in promoting vision and enhances immune system functioning. Beta-carotene which is a precursor of vitamin A is an antioxidant, that can be obtained from many foods. It is recommended to take vitamin A in small doses and foods that rich in vitamin A are sweet potatoes, carrots, milk, paprika, turnips, lettuce and apricots.

3. Vitamin B6

Vitamin B6 is a water soluble vitamin, which helps in the functioning of several enzymatic reactions. It is also involved in different metabolisms and synthesis of hemoglobin. Pyridoxal phosphate is the active form of vitamin B6 to act as a co-enzyme with other enzymes that are particularly involved in metabolic activities.

Vitamin B6 is also an antioxidant, helps in controlling the levels of homocysteine and improves digestive functioning. The food sources that are having vitamin B6 are avocados, meat, nuts, poultry, whole grains, bananas and legumes.

4. Vitamin B12

Vitamin B12 is an important vitamin that functions the nervous system and helps in the formation of blood. It is a part of the B vitamins and is water soluble. Vitamin B12 is also required to make DNA and the genetic material in the cells.

Naturally vitamin B12 is bound to the proteins and only when the stomach releases hydrochloric acid, vitamin B12 gets separated. People with gastritis needs to take high doses of vitamin B12 to get absorbed properly. Foods that are rich in vitamin B12 are oysters, liver, octopus, crab, beef, cheese and fish.

5. Vitamin E

Vitamin E is a fat soluble compound required for many biological functions. It is an antioxidant which prevents accumulation of the free radicals in the tissues. It can be easily propagated into cell membranes to protect them from oxidation damage.

Vitamin E helps in soothing the stomach and periodically heals the lining of the stomach. By taking vitamin E as a part of the diet, one can reduce the inflammation and cure the gastritis. Foods that are rich in vitamin E are almonds, pine nuts, sunflower seeds, basil, apricots and peanuts.

Source: vitaminsestore.com

Key Regulator of Intestinal Homeostasis Identified

SP140, an epigenetic reader protein mutated in a number of autoimmune disorders, is essential for macrophage function and preventing intestinal inflammation, scientists show. 

Read more: Key Regulator of Intestinal Homeostasis Identified

Artist's rendition of a macrophage in the gut and epigenome (green balls are the basic units of chromatin,
with nucleosomes wrapped twice around an octamer of a histone)

Researchers are only beginning to understand the roles of the hundreds of proteins involved in reading, writing, and erasing the epigenome. One of the epigenetic regulators, SP140, which is mutated in a number autoimmune disorders, including Crohn’s disease and multiple sclerosis, is also essential to macrophage function and intestinal homeostasis in both humans and mice, scientists reported today (March 3) in Science Immunology.

“Many immune-mediated disorders are driven by a combination of genetic susceptibility as well as environmental influences [so] epigenetics is a suitable critical juncture between those two aspects of the disease,” said coauthor Kate Jeffrey, a researcher investigating the epigenetic control of innate immunity at Massachusetts General Hospital.

Source: the-scientist

How to Get Rid of a Stuffy Nose: Eight Possible Treatments

Nasal congestion is a very common condition. In fact, most people get a stuffy nose from time to time.

Nasal congestion can develop when the blood vessels inside the nose become inflamed and the nasal tissues swell. Excess mucus drainage may also occur with a stuffy nose.

This article will look at eight possible treatments for a stuffy nose.

Read more: How to Get Rid of a Stuffy Nose: Eight Possible Treatments

Nasal congestion is very common and can be treated in a variety of ways. A neti pot is of Indian origin
and is used to flush the sinuses. A stuffy nose should clear after 10 days. If symptoms persist, a doctor
should be consulted.

Source: MedicalNewsToday

From 230,000 patients to extinct in 15 years: pathology and new drugs key to defeating hepatitis C

An estimated 230,000 Australians have chronic hepatitis C, and a quarter of cases are undiagnosed.

Hepatitis C inflames the liver and unlike the A and B viruses there is no vaccine available. Pathology is important for diagnosing the virus.

Many people with hepatitis C may not experience symptoms, but left untreated the disease can cause cirrhosis (scarring of the liver), which in a small number of cases can lead to liver cancer.

Read more: From 230,000 patients to extinct in 15 years: pathology and new drugs key to defeating hepatitis C

Source: knowpathology

Hepatitis C: Signs and Symptoms

When the liver becomes inflamed due to infection, disease, drugs, poisons, or excessive alcohol, it is referred to as hepatitis. Infectious hepatitis commonly includes hepatitis A, B, or C. All of these forms are caused by viral infections.

The liver is a two-lobed organ found in the upper-right part of the torso. It is responsible for many functions and substances within the body,

Read more: Hepatitis C: Signs and Symptoms

Hepatitis occurs when the liver becomes inflamed due to infection, disease, drugs, poisons, or
excessive alcohol. HCV can spread through needle sharing. Testing for HCV is important if a
patient is experiencing any of the symptoms.

Source: medicalnewstoday

Serum Albumin Levels Associated with Mortality in Hemodialysis Patients

Serum albumin is commonly used as a proxy for nutritional status, as well as a marker of inflammation and a low serum albumin concentration is not only indicative of protein energy wasting in dialysis patients, but it is also a powerful predictor of the mortality risk in this population.

Several clinical conditions are associated with low serum albumin levels in dialysis patients, including infectious and inflammatory diseases, fluid overload, inadequate dialysis, severe co-morbidity, and taste change. Therefore, regular monitoring of serum albumin levels is useful for predicting outcomes in dialysis patients.

Read more: Enlarged Prostate: Molecular Mechanism Clue May Explain Link To Inflammation

The Hitachi 7600–210 modular clinical biochemistry analyzer (Photo courtesy of Hitachi).

Source: labmedica

Enlarged Prostate: Molecular Mechanism Clue May Explain Link To Inflammation

A new study reveals an important molecular clue about how inflammation may lead to prostate enlargement or benign prostatic hyperplasia. The researchers believe their discovery may also lead to ways of overcoming resistance to androgen-targeted treatment for the condition.

Enlarged prostate or benign prostatic hyperplasia (BPH) is a common condition in older men where the prostate gland is enlarged and not cancerous.

As the prostate gland enlarges, it presses against and pinches the urethra, the tube that allows urine to leave the bladder. Also, the bladder wall gradually thickens and the bladder may get weaker and lose the ability to empty completely.

Read more: Enlarged Prostate: Molecular Mechanism Clue May Explain Link To Inflammation

Enlarged prostate or benign prostatic hyperplasia (BPH) is a common condition in older men.

Source: medicalnewstoday

Cracking the Enigma of Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) affects one out of four people in the world, making it the most prevalent of all liver diseases and a major public health problem. The disease is defined by abnormally increased fat deposition in liver cells, which can progress with the addition of inflammation and cell damage to nonalcoholic steatohepatitis (NASH), leading to progressive stages of fibrosis and, finally, cirrhosis. Early NASH is characterized by fat and inflammation associated with minimal amounts of fibrosis, and late NASH is associated with advanced fibrosis or cirrhosis. NAFLD is most closely associated with obesity and diabetes, although there are likely other genetic, nutritional, and environmental factors involved in the pathogenesis.

Although there are no approved pharmacologic treatments for NAFLD, NASH, or cirrhosis, there are over a dozen different companies researching possible treatments. However, the development of drug therapies for the NAFLD spectrum of disease is hampered by a number of challenges:

• the chronic nature of the disorder and ultimately low morbidity and mortality,
• the impact of weight loss on the disease,
• a complex and poorly defined pathophysiology,
• the lack of easily administered diagnostic testing, and
• the evolving status of regulatory endpoints.

Read more: Cracking the Enigma of Fatty Liver Disease

The results of multiple clinical trials over the next few years will clarify potential therapies and target
pathways.  © Sebastian Kaulitzki/Fotolia]

Source: genengnews

All You Need to Know About Nephritis

To understand kidney problems such as nephritis, it's helpful to start with some background on what the kidneys are, and what they do.

The kidneys are two bean-shaped, fist-sized organs found just under the ribs on the left and right sides of the spine. They remove impurities and extra water from the blood, filtering 120-150 quarts of blood a day, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

Each kidney consists of thousands of structures called nephrons, where the actual blood filtering takes place. In the nephron, a two-step cleaning process separates what the body needs to keep from what it can get rid of.

A filter called the glomerulus catches blood cells and protein, sending water and waste to a second filter, called a tubule. The tubule captures minerals. After that, what remains leaves the body as urine.

Read more: All You Need to Know About Nephritis

Nephritis can lead to kidney failure if not treated. There are various ways of preventing kidney damage
if someone has symptoms of nephritis. Monitoring blood pressure is important if kidney problems
develop.

Source: medicalnewstoday

Bacterial Pneumonia - Get the Facts

Bacterial pneumonia is an inflammation of the lungs due to some form of bacteria. There are different types of bacteria that may lead to the infection.

The lungs are made up of different sections or lobes. There are three lobes on the right and two on the left. Bacterial pneumonia can affect both lungs, one lung, or even just one section of a lung.

The lobes of the lungs are made up of small air sacs called alveoli. Normally, the air sacs fill with air. Oxygen is inhaled and carbon dioxide in exhaled.

When a person develops pneumonia, the air sacs become inflamed, which can cause them to fill with fluid. If the air sacs are filled with fluid instead of air, it can make breathing difficult. In some cases, the lungs may not get enough oxygen.

Read more: Bacterial Pneumonia - Get the Facts

Bacteria that cause pneumonia are spread through coughing. Doctors will carry out a chest X-ray to

assess fluid buildup in the lungs. An annual flu vaccine can help prevent pneumonia.

Source: medicalnewstoday

Appendicitis: Warning Signs and Early Symptoms

Appendicitis is a condition in which the appendix becomes inflamed. Its symptoms can become very uncomfortable, painful, and potentially life-threatening if left untreated.

Sudden appendicitis is the most common cause of acute abdominal pain requiring surgery in the United States. Additionally, more than 5 percent of the population develops appendicitis at some point.

Though it most commonly occurs between the ages of 10 and 30, appendicitis can develop at any age.

Read more: Appendicitis: Warning Signs and Early Symptoms

The appendix is a tube-shaped piece of tissue attached to part of the long intestine and severe pain is
often the first symptom of appendicitis. In most cases, it will begin near the belly button and surgery
may be needed to treat a case of appendicitis.

Source: medicalnewstoday

Identifying and Treating Inflammation

There are three types of inflammation: acute, chronic and life-threatening.

When basketball star Steph Curry slipped and injured his knee in late April, he reacted by tearing up on the sideline, while fans and media reacted by wondering how many games he would miss. His body? It reacted by inflaming around the outside of the knee, protecting the area as it recovered from a medial collateral ligament sprain.

The word inflammation can conjure up visuals of a swollen, red and throbbing knee or, thanks to some TV ads, a lit match doused by a medicated pad. Conventional public wisdom frames inflammation as being adverse, painful and harmful – something most people want to resolve quickly with medication.

Read more: Identifying and Treating Inflammation

Treat acute inflammation by managing it, not trying to cure it.

Source: Getty Images

Breast milk hormones found to impact bacterial development in infants' guts

Intestinal microbiome of children born to obese mothers significantly different from those born to mothers of healthy weight

A new study finds that hormones in breast milk may impact the development of healthy bacteria in infants' guts, potentially protecting them from intestinal inflammation, obesity and other diseases later in life.

The study, published Monday in the American Journal of Clinical Nutrition, examines the role of human milk hormones in the development of infants' microbiome, a bacterial ecosystem in the digestive system that contributes to multiple facets of health.

"This is the first study of its kind to suggest that hormones in human milk may play an important role in shaping a healthy infant microbiome," said Bridget Young, co-first author and assistant professor of pediatric nutrition at CU Anschutz. "We've known for a long time that breast milk contributes to infant intestinal maturation and healthy growth. This study suggests that hormones in milk may be partly responsible for this positive impact through interactions with the infant's developing microbiome."

Researchers found that levels of insulin and leptin in the breast milk were positively associated with greater microbial diversity and families of bacteria in the infants' stool.

Read more: Breast milk hormones found to impact bacterial development in infants' guts

A new study examined the role of human milk hormones in the development of infants' microbiome

Source: ricardoferrando/Fotolia

Immune cells self-healing brain after stroke

After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair.

"This is in total contrast to our previous beliefs", says Professor Zaal Kokaia from Lund University in Sweden.

Zaal Kokaia, together with Professor of Neurology Olle Lindvall, runs a research group at the Lund Stem Cell Center that, in collaboration with colleagues at the Weizmann Institute in Israel, is responsible for these findings. Hopefully, these new data will lead to new ways of treating stroke in the future. The study was recently published in the Journal of Neuroscience.

When stroke occurs, the nerve cells in the damaged area of the brain die, causing an inflammation that attracts cells from the immune system. Among them you find monocytes—a type of white blood cells produced in the bone marrow.

Read more: Immune cells self-healing brain after stroke

False-colored scanning electron micrograph of a blood clot. There are many red blood cells and

a single white blood cell held together in a meshwork of fibrin (brown).

Source: Anne Weston, LRI, CRUK, Wellcome Images

Atherosclerosis, Rheumatoid Arthritis and Inflammation.

Rheumatoid arthritis (RA) has long been associated with increased cardiovascular risk, but despite substantial improvements in disease management, mortality remains high. Atherosclerosis is more prevalent in RA than in the general population, and atherosclerotic lesions progress at a faster rate and might be more prone to rupture, causing clinical events. Cells and cytokines implicated in RA pathogenesis are also involved in the development and progression of atherosclerosis, which is generally recognized as an inflammatory condition. The two diseases also share genetic and environmental risk factors, which suggests that patients who develop RA might also be predisposed to developing cardiovascular disease. In RA, inflammation and atherosclerosis are closely linked. Inflammation mediates its effects on atherosclerosis both through modulation of traditional risk factors and by directly affecting the vessel wall. Treatments such as TNF inhibitors might have a beneficial effect on cardiovascular risk. However, whether this benefit is attributable to effective control of inflammation or whether targeting specific cytokines, implicated in atherosclerosis, provides additional risk reduction is unclear. Further knowledge of the predictors of cardiovascular risk, the effects of early control of inflammation and of drug-specific effects are likely to improve the recognition and management of cardiovascular risk in patients with RA.

Rheumatoid arthritis (RA) is associated with a significantly increased risk of cardiovascular mortality, accounted for mainly by increased atherosclerotic disease.1, 2 Although the prevalence of some traditional cardiovascular risk factors is increased in RA, adjustment for these factors does not fully account for the heightened risk, suggesting that RA itself is an independent risk factor for cardiovascular disease (CVD).3 The prevalence of atherosclerosis is increased in RA, even in early disease,4 and chronic inflammation is thought to promote atherosclerosis both by modulation of traditional risk factors and also possibly by direct biological effects on the artery. In this article, we discuss the potential mechanisms that might accelerate atherosclerosis in RA, with a particular focus on inflammation.

Read more: Atherosclerosis, Rheumatoid Arthritis and Inflammation.

Figure 2: Development of an atherosclerotic plaque.

Source: NatureReviewsRheumatology