Association Between Genetic Variation And Influenza Severity.

It is estimated that in the USA influenza -related deaths in recent years have ranged from 12,000 to 56,000. Factors like age, obesity, pregnancy and such chronic health conditions as asthma, chronic lung disease and heart disease are associated with an elevated risk of complications and death.

However, there are no proven genetic markers of influenza risk with an established mechanism of action. Interferon Induced Transmembrane Protein 3 (IFITM3) is an anti-viral protein that helps to block influenza infection of lung cells and to promote survival of the killer T cells that help clear the infection in the airways.

Image: A scanning electron micrograph of a CD8+ T cell engaging a virus.

(Photo courtesy of Dennis Kunkel).

A group of scientists collaborating with those at St. Jude Children's Research Hospital (Memphis, TN, USA) searched for other possible IFITM3 variants that correlated with gene expression, levels of the IFITM3 proteins and were common in influenza patients in the USA. The search led to an IFITM3 variant known as rs34481144. They checked 86 children and adults in Memphis with confirmed influenza infections and found two-thirds of patients with the most severe symptoms carried at least one copy of the newly identified high-risk IFITM3 variant. The high-risk variant was found in just 32% of patients with milder symptoms.

The team also found an association between the newly identified high-risk variant and severe and fatal influenza infections in 265 critically ill pediatric patients hospitalized in one of 31 intensive care units nationwide. The patients did not have health problems that put them at high risk for severe influenza. Of the 17 patients in this group who died from the infection, 14 carried at least one copy of the newly identified high-risk variant. Further study revealed how binding differed between the high-risk and protective variants. Those differences led to lower levels of the IFITM3 protein in individuals with two copies of the high-risk gene variant compared to other patients. The Memphis influenza patients also had fewer of the killer T cells in their upper airways. The study identifies a new regulator of IFITM3 expression that associates with CD8+ T cell levels in the airways and a spectrum of clinical outcomes.

Paul Thomas, PhD, an immunologist and corresponding author of the study, said, “A genetic marker of influenza risk could make a life-saving difference, particularly during severe influenza outbreaks, by helping prioritize high-risk patients for vaccination, drug therapy and other interventions. These results raise hopes that this newly identified IFITM3 variant might provide such a marker.” The study was published on July 17, 2017, in the journal Nature Medicine.

Source: labmedica

Antibiotics In Early Life Could Raise Children's Food Allergy Risk

Infection in the first year of life can be deadly for an infant, and antibiotic treatment is often the first port of call. But such treatment may have a downside; new research from the University of South Carolina finds early antibiotic exposure could raise a child's risk of food allergies.

While the study did not investigate the reasons behind this association, the researchers say it is likely down to changes in gut microbiota as a result of antibiotic treatment.

Lead author Dr. Bryan Love, of the Department of Clinical Pharmacy and Outcomes Sciences at the South Carolina College of Pharmacy, and colleagues report their results in the journal Allergy, Asthma & Clinical Immunology.

Previous research has suggested that changes to the composition of gut bacteria in early life can have negative implications for health, and antibiotics are known to do just that.

Read more: Antibiotics In Early Life Could Raise Children's Food Allergy Risk

Early antibiotic exposure could raise children's risk of food allergies.

Source: medicalnewstoday

Breast-Feeding May Reduce Asthma Symptoms For At-Risk Infants

A new study provides further evidence of the health benefits of breast-feeding, after finding infants with a genetic susceptibility for asthma development are less likely to experience symptoms of the condition if they are breast-fed.

Asthma is estimated to affect around 8.6 percent of children and adolescents in the United States, making it one of the most common chronic childhood diseases.

Asthma symptoms are the same for children as for adults; these include wheezing, coughing, breathing problems, and chest tightness. However, because children have smaller airways, symptoms may be more severe.

As a result, asthma is the third leading cause of hospital stays and a leading cause of missed school days for children in the U.S.

While the precise causes of asthma remain unclear, studies have suggested the respiratory condition may arise as a result of environmental and genetic factors.

Read more: Breast-Feeding May Reduce Asthma Symptoms For At-Risk Infants

Breast-feeding may reduce respiratory symptoms for children genetically susceptible to asthma
development.

Source: medicalnewstoday

Bacterial Pneumonia - Get the Facts

Bacterial pneumonia is an inflammation of the lungs due to some form of bacteria. There are different types of bacteria that may lead to the infection.

The lungs are made up of different sections or lobes. There are three lobes on the right and two on the left. Bacterial pneumonia can affect both lungs, one lung, or even just one section of a lung.

The lobes of the lungs are made up of small air sacs called alveoli. Normally, the air sacs fill with air. Oxygen is inhaled and carbon dioxide in exhaled.

When a person develops pneumonia, the air sacs become inflamed, which can cause them to fill with fluid. If the air sacs are filled with fluid instead of air, it can make breathing difficult. In some cases, the lungs may not get enough oxygen.

Read more: Bacterial Pneumonia - Get the Facts

Bacteria that cause pneumonia are spread through coughing. Doctors will carry out a chest X-ray to

assess fluid buildup in the lungs. An annual flu vaccine can help prevent pneumonia.

Source: medicalnewstoday

Can we really outgrow asthma?

If you're one of the 25 million Americans who have asthma, you probably want to know if you're always going to be living with it. If you're a parent of one of the 7 million U.S. children with asthma, you probably want to know if your child might outgrow it. The short answer: That depends. Here's why.

Can Children Outgrow Asthma?

About half of all children with asthma start having symptoms before age five. However, it's hard to diagnose asthma in a child under age five. That's because the lung function tests that are most important for making the diagnosis are too hard for a young child to perform.

If you have a child with asthma symptoms, there is about a 50% chance your child will outgrow the symptoms. But there's also a 25% chance those symptoms will come back once the child is an adult. This means the chance of your child permanently outgrowing asthma is about 25%.

Read more: Can we really outgrow asthma?

Source: healthgrades

Doctors are over-diagnosing children asthma.

Inhalers often dispensed for no good reason and have 'almost become a fashion accessory'

Doctors are overdiagnosing asthma, with inhalers frequently dispensed for no good reason, to the point that they have "almost become a fashion accessory," argue two leading respiratory doctors in a leading article published online in the Archives of Disease in Childhood.

In the past asthma was undoubtedly underdiagnosed, but the evidence now is that the pendulum has swung too far in the opposite direction, insist Professor Andrew Bush and Dr Louise Fleming of Imperial College and Royal Brompton & Harefield NHS Foundation Trust, in the journal.

It matters, not only because of the cost of inhalers, but also because of their side effects, which are more likely to occur in patients who are prescribed an inappropriate dose, they say.

"Inhaled corticosteroids, when properly used, dramatically improve quality of life and reduce the risk of asthma attacks and mortality," they write.

Read more: Doctors are over-diagnosing children asthma.

If the past asthma was undoubtedly underdiagnosed, but the evidence now is that
he pendulum has swung too far in the opposite direction, insist experts in a new article.

Source: sciencedaily (crystal kirk/Fotolia)