How to Increase Laboratory Accuracy with Direct HbA1c Testing !

HbA1c:

Diabetes is a global epidemic affecting in the region of 425 million people according to the International Diabetes Federation. Worryingly, this figure is on the rise with forecasts suggesting diabetes will affect up to 629 million people globally by 2045. Such a dramatic increase highlights the fundamental need for better disease management. When we look at the worldwide prevalence of diabetes, the United States is one of the most prominent countries affected.

HbA1c - an important biomarker for diabetes management and control !

HbA1c, also known as hemoglobin A1c or glycated hemoglobin, is an important blood test used to determine how well diabetes is being controlled. It develops when hemoglobin, a protein within the red blood cells that carries oxygen throughout the body, joins with glucose in the blood, becoming “glycated.” The concentration of HbA1c in the blood of diabetic patients increases with rising blood glucose levels and is representative of the mean blood glucose level over the preceding six to eight weeks. HbA1c can therefore be described as a long-term indicator of diabetic control, unlike blood glucose which is only a short-term indicator of diabetic control. It is recommended that HbA1c levels are monitored every three to four months.

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Amino Acids in Cancer Metabolism and Neuroscience

These Building Blocks Could Be Valuable Tools for Research

Amino acids are important building blocks for protein synthesis and are also intermediary metabolites that fuel biosynthetic reactions, thus playing a dual role in cellular metabolism. Accurate quantification of L-amino acids in body fluids or purified samples may provide valuable information for diagnostic and basic research studies.

Cellular Roles of Amino Acids in Cancer and Neurobiology

Cancer cells have altered metabolism and are known for their metabolic abnormalities. One example is the Warburg effect, in which there is increased glycolytic activity even in the presence of oxygen. Cancer cells depend on a high rate of aerobic glycolysis for continued growth and survival.

Read more: Amino Acids in Cancer Metabolism and Neuroscience

Figure 1. Glutamine and the metabolism of other amino acids as targets for cancer therapy.

[Int J Mol Sci 2015;16:22830–22855; doi:10.3390/ijms160922830]

Source: genengnews

Bacterial Pneumonia - Get the Facts

Bacterial pneumonia is an inflammation of the lungs due to some form of bacteria. There are different types of bacteria that may lead to the infection.

The lungs are made up of different sections or lobes. There are three lobes on the right and two on the left. Bacterial pneumonia can affect both lungs, one lung, or even just one section of a lung.

The lobes of the lungs are made up of small air sacs called alveoli. Normally, the air sacs fill with air. Oxygen is inhaled and carbon dioxide in exhaled.

When a person develops pneumonia, the air sacs become inflamed, which can cause them to fill with fluid. If the air sacs are filled with fluid instead of air, it can make breathing difficult. In some cases, the lungs may not get enough oxygen.

Read more: Bacterial Pneumonia - Get the Facts

Bacteria that cause pneumonia are spread through coughing. Doctors will carry out a chest X-ray to

assess fluid buildup in the lungs. An annual flu vaccine can help prevent pneumonia.

Source: medicalnewstoday