New Understanding Of Pulmonary Hypertension Leads To Promising Drug Targets

A groundbreaking new study led by researchers from the University of Pittsburgh and UPMC has identified a new group of compounds that could have robust effects in treating pulmonary hypertension (PH), an enigmatic but sometimes fatal disease of the blood vessels of the lungs that currently has no cure. The findings, which were published today in the Journal of Clinical Investigation, highlight the use of these drugs to alter vessel stiffness and its downstream control of metabolism, a link previously unknown for people suffering from the progressive disease.

“If we aim to cure this disease, the next set of medications and treatments should be those that target the origin at the molecular level,” said Stephen Y. Chan, M.D., Ph.D., director of the UPMC Center for Pulmonary Vascular Biology and Medicine at the Vascular Medicine Institute at Pitt, and senior author of the study. “As a community, we are struggling right now to understand those origins of PH, and this study aimed to address that untapped need.”

Read more: New Understanding Of Pulmonary Hypertension Leads To Promising Drug Targets

Source: bioengineer

All You Need to Know About Nephritis

To understand kidney problems such as nephritis, it's helpful to start with some background on what the kidneys are, and what they do.

The kidneys are two bean-shaped, fist-sized organs found just under the ribs on the left and right sides of the spine. They remove impurities and extra water from the blood, filtering 120-150 quarts of blood a day, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

Each kidney consists of thousands of structures called nephrons, where the actual blood filtering takes place. In the nephron, a two-step cleaning process separates what the body needs to keep from what it can get rid of.

A filter called the glomerulus catches blood cells and protein, sending water and waste to a second filter, called a tubule. The tubule captures minerals. After that, what remains leaves the body as urine.

Read more: All You Need to Know About Nephritis

Nephritis can lead to kidney failure if not treated. There are various ways of preventing kidney damage
if someone has symptoms of nephritis. Monitoring blood pressure is important if kidney problems
develop.

Source: medicalnewstoday

Stroke Could be Better Predicted with Biomarker Discovery

Stroke is a leading cause of disability and death in the United States, affecting more than 795,000 Americans every year. But what if doctors were better able to predict who is likely to have a stroke, providing greater opportunity for prevention? Researchers have uncovered four biomarkers that could help do just that.

In a study published in the journal Neurology, researchers found that individuals who had higher levels of four inflammatory biomarkers in their blood were at greater risk for stroke than those with lower levels.

Study co-author Dr. Ashkan Shoamanesh, of McMaster University in Canada, and colleagues say that - while further research is needed to determine whether these biomarkers could be used in clinical practice - their findings could pave the way for better prevention and treatment of stroke.

Stroke occurs when the flow of oxygen-rich blood to the brain is reduced, causing brain cell death.

Read more: Stroke Could be Better Predicted with Biomarker Discovery

Researchers have pinpointed four biomarkers that they say could help predict stroke risk.

Source: medicalnewstoday

Gallstones Raise the Risk of Heart Disease by a Fifth

A new meta-analysis, using data from hundreds of thousands of individuals, finds that gallbladder disease and heart disease are more intertwined than previously thought. The reasons behind this connection are, as yet, unclear.

Gallstones are small, hard deposits that form in the gallbladder - an organ that sits below the liver.

In wealthier countries, they are a common occurrence, affecting 10-15 percent of all adults.

Gallstones are thought to be produced due to an imbalance in the makeup of bile - a digestive aid produced by the liver and concentrated in the gallbladder.

Although generally small and often symptomless, over the years, gallstones can grow to the size of pebbles.

Read more: Gallstones Raise the Risk of Heart Disease by a Fifth

Gallstones' links to heart disease run deeper than previously thought.

Source: medicalnewstoday

What Happens to Your Body When You Stop Smoking

The process your body goes through after stopping smoking - in the 20 minutes to 15 years after your last cigarette - has been revealed by CVS health.

Around 10 million people in the UK smoke, and about two thirds of them want to stop, according to research from Action on Smoking and Health (ASH).

About half of all regular smokers will die from their addiction, which amounts to about 100,000 people a year.

The infographic from CVS Health (click to enlarge) revealed that 20-30 minutes after smoking cessation blood pressure and pulse have already started to drop, and the carbon monoxide in the blood will begin to drop after just eight hours.

Read more: What Happens to Your Body When You Stop Smoking

A year after you stop smoking, your risk of heart disease will be half that of a smoker

Source: msn.com/en-ca/health/medical

Video: Biomedical Video: The Best Method to Quit Smoking

Science Behind Power Naps

With a very busy schedule and too much on our plate, we are not getting enough sleep nowadays. Sleep deprivation is very bad for the health and is giving rise to a number of diseases nowadays. Diseases like heart problems, fluctuations in sugar levels, high and low blood pressures and thyroid issues have become very common in sleep deprived individuals. This is where power naps can help.

When you sleep during the day between 1 PM and 4 PM for a period lasting between ten to thirty minutes, it is known as a power nap. If you sleep longer than thirty minutes, you might develop sleep inertia, a groggy feeling. You should also not sleep later than 4 PM as then you will find it difficult to sleep at night.

Read more: Science Behind Power Naps

Source: boldsky

Heart Attack Risk is Lower When Immune System is More Robust

Could a robust immune system protect against heart attack? After studying a group of patients with high blood pressure, researchers found those with higher levels of certain antibodies had a lower risk of heart attack - regardless of other risk factors. They suggest a blood test to measure antibody levels could help assess a person's risk of heart attack.

The study, from Imperial College London in the United Kingdom, is published in the journal EbioMedicine. It describes how the team discovered a link between blood levels of Immunoglobulin G (IgG) antibodies and reduced chances of having a heart attack.

Lead investigator Dr. Ramzi Khamis, a consultant cardiologist and clinical research fellow, says:

"Linking a stronger, more robust immune system to protection from heart attacks is a really exciting finding. As well as improving the way we tell who is at the highest risk of a heart attack so that we can give them appropriate treatments, we now have a new avenue to follow in future work."

Read more: Heart Attack Risk is Lower When Immune System is More Robust

The study found higher blood levels of an antibody called IgG were linked to lower risk of heart attack
in a group of people with high blood pressure.

Source: medicalnewstoday

How Much Salt is Too Much?

Salt intake has become a major health concern in the United States. An array of studies have claimed too much salt in the diet can increase the risk of serious illness, such as heart disease and stroke, prompting recommendations to lower salt intake. But how much is "too much" when it comes to salt consumption?

The Dietary Guidelines for Americans recommend that adults consume less than 2,300 milligrams of sodium each day - the equivalent to around 1 teaspoon of salt - as part of a healthy diet.

A report from the Centers for Disease Control and Prevention (CDC) released earlier this year, however, found that around 90 percent of adults and children in the U.S. consume more than the recommended sodium intake, with most adults consuming more than 3,400 milligrams daily.

Read more: How Much Salt is Too Much?

Current guidelines recommend limiting salt intake to less than 2,300 milligrams daily.

Source: medicalnewstoday