We could be close enough to the stem cell revolution!

Stem cell therapy has been in use for many years, but with only limited reach. As such the oft bandied stem cell revolution has still yet to arrive. Steve Buckwell and Chris Coe explain why this is set to change and why now is the perfect time for its potential to be achieved. 

The stem cell revolution as it’s often referred to is now already in its third decade. But like the paper free office, is it just one of those envisaged futures that never seem to really happen? Embryonic stem cells were first isolated 18 years ago, but stem cell therapies have been slowed by high production costs, batch-to-batch variability and limited seed material. But we still believe the revolution will kick off some time in the second half of this decade. This is why.

Firstly the early ethical issues have, in many cases been overcome, with adult stem cells showing promise in the clinic but not requiring the embryo exploitation and destruction that made embryonic stem cell research so controversial in the years after 1998. Secondly, there is now substantial mid-stage clinical evidence that stem cells work in areas of unmet medical need, much of which has only become evident in the last five years.

There are various stem cell products in development that work allogeneically, meaning that the patient receives stem cells sourced from someone else’s body. As a general rule, allogeneic therapies are quite cost effective because they have the potential to be ‘off-the-shelf’, whereas autologous therapies (use of the patient’s own cells) can be considerably more expensive.

Read more: We could be close enough to the stem cell revolution!

Source: labnews

Novel test can detect any virus

Scientists have designed a test that can detect not only any known virus type and subtype but also virus outbreaks.

A research team led by the Washington University School of Medicine in St Louis (WUSTL) condensed nearly 1 billion base pairs of viral DNA sequences to create a test that they call ViroCap.

“With this test, you don’t have to know what you’re looking for. It casts a broad net and can efficiently detect viruses that are present at very low levels. We think the test will be especially useful in situations where a diagnosis remains elusive after standard testing or in situations in which the cause of a disease outbreak is unknown,” said research associate Professor Gregory Storch.

To develop the test, the researchers targeted unique stretches of DNA or RNA from every known group of viruses that infects vertebrates – including 2 million unique stretches of genetic material. The stretches of material were used as probes which can pluck out viruses from a sample and find a genetic match. The matched viral material was then analyzed by high-throughput genetic sequencing.

Read more: Novel test can detect any virus

New test can detect any virus that infects vertebrates

Source: labnews

Insights on the Growing Fingerprint Challenge

Although some fingerprint analysis is new, the concept—using fingerprints for identification—started centuries ago.

The Future of Identifying People Will Require More Than One Method

Standing in the immigration line at the Indira Gandhi International Airport in Delhi, India, I watch person after person be fingerprinted. First, you put your left four fingers on a digital pad, then your right four, and finally both thumbs at once. If all goes smoothly, the Indian government collects all ten fingerprints for everyone entering the country. It’s not as easy as it sounds, even from the start. More than one person is asked to try again and again. So obtaining a print can be as difficult as analyzing one.

Although some fingerprint analysis is new, the concept— using fingerprints for identification—started centuries ago. Thousands of years ago in Babylon, a fingerprint served as a signature of sorts on business papers. Finally, in 1880, British surgeon Henry Faulds described using fingerprints to identify people; he gets credit for the first use of this technology of lifting a print from an alcohol bottle.

Read more: Insights on the Growing Fingerprint Challenge

Source: labmanager

Next Generation Blood Separation Technology

A next-generation blood separation technology that is designed to enhance sample quality, improve laboratory efficiency and reduce laboratory turnaround time has received the Conformité Européenne (CE) marking. 

The tube is a single-use, plastic evacuated tube used to collect, separate, transport and process venous blood specimens to obtain high-quality plasma for in vitro diagnostic use and the tube has a revolutionary separator technology, providing a cleaner plasma sample with less cellular contamination, meaning the sample is more stable and allows a longer window to conduct testing when compared to existing blood separation tubes. 

BD Barricor tubes (BD, Becton, Dickinson and Company, Franklin Lakes, NJ, USA) are optimized to deliver a high quality plasma sample by reducing cellular content (versus plasma gel tubes), as a result of the mechanical separator remaining open throughout the centrifugation cycle.

Read more: Next Generation Blood Separation Technology

BD vacutainer separation tubes for blood specimens

Source: Becton, Dickinson, and Company

Heart Attack Patients Are Getting Younger and More Obese.

Young people tend to feel invincible to danger, but they're not, especially when it comes to their heart health. One of the most common misconceptions about heart health is that older people are the only ones who need to worry. 

Patients who suffer from the most severe and deadly type of heart attack, STEMI, are getting younger and more obese, according to Dr. Samir Kapadia, professor of medicine and section head for interventional cardiology at Cleveland Clinic.

"On the whole, the medical community has done an outstanding job of improving treatments for heart disease, but this study shows that we have to do better on the prevention side," said Kapadia in a statement. "When people come for routine checkups, it is critical to stress the importance of reducing risk factors through weight reduction, eating a healthy diet, and being physically active." He presented his research at the American College of Cardiology's 65th Annual Scientific Session.

Read more: Heart Attack Patients Are Getting Younger and More Obese.

Video link: Younger obese people are at risk of getting heart attacks!

Source: HealthDay

Tips to diabetes for drinking alcohol

Enjoying a glass of wine, fruity margarita, or frosty pint of beer requires a little forethought if you have diabetes. Before you indulge, make sure you have a tasty appetizer or healthy salad to go along with your drink. And talk to your doctor about drinking alcohol. The answer to whether you can or should not will depend on your specific circumstances.

How Does Alcohol Affect Blood Sugar?

The way alcohol affects your blood sugar comes down to whether you’ve eaten, and how much and how often you drink. A standard drink contains 0.6 fluid ounces of alcohol. This means that a 12 ounce beer (about 5% alcohol) is equivalent to a 5 ounce glass of your average table wine (about 12% alcohol) or a shot of hard liquor such as vodka. Here’s the scoop on how much and how often:

• When you have an occasional drink with food, alcohol generally has little effect on your blood sugar. This is the safest way to enjoy alcohol.
• When you have an occasional drink without any food, alcohol can cause your blood sugar to fall to dangerously low levels. You should never drink alcohol on an empty stomach.
• If you are a habitual drinker (3 to 4 drinks a day), alcohol increases your blood sugar no matter what you eat. If this describes you, consider talking to your doctor about ways to cut back or stop your alcohol use.

Read more: Tips to diabetes for drinking alcohol

Source: diabeteszone

'Millions will die' from antimicrobial resistance unless we act now

From helping humans live longer and hacking our performance, to repairing the body and understanding the brain, WIRED Health will hear from the innovators transforming this critical sector.

Ten million people around the world will die each year by 2050 if more is not done to tackle the growing threat of antimicrobial resistance, Jim O'Neill, commercial secretary to the treasury, has said.

Speaking at WIRED Health, O'Neill said the rise in resistance needs to be "embraced by policy makers around the world".

If it isn't then the number of people dying from antimicrobial resistance (AMR) will increase dramatically.

Read more: 'Millions will die' from antimicrobial resistance unless we act now

Staphylococcus Aureus

Source: Getty Images / BSIP

Lab-grown sperm makes healthy offspring

Sperm have been made in the laboratory and used to father healthy baby mice in a pioneering move that could lead to infertility treatments.

The Chinese research took a stem cell, converted it into primitive sperm and fertilised an egg to produce healthy pups.

The study, in the Journal Cell Stem Cell, showed they were all healthy and grew up to have offspring of their own.

Experts said it was a step towards human therapies.

It could ultimately help boys whose fertility is damaged by cancer treatment, infections such as mumps or those with defects that leave them unable to produce sperm.

Sperm factory

Making sperm in the testes is one of the longest and most complicated processes in the body - taking more than a month from start to finish in most mammals.

Read more: Lab-grown sperm makes healthy offspring

Source: bbc

Scientists are growing billions of blood cells in the lab

From helping humans live longer and hacking our performance, to repairing the body and understanding the brain, WIRED Health will hear from the innovators transforming this critical sector. Read all of our WIRED Health coverage here.

Jo Mountford is making billions of red blood cells in a laboratory in Glasgow. And now she wants to scale-up production. Big time.

Mountford, from the Institute of Cardiovascular and Medical Sciences at the University of Glasgow, started trying to create blood in the lab in 2007 and is now able to create it on demand.

In 2008, her team produced 100,000 red blood cells; by 2014 output had reached ten billion cells for the year. The ten billion cells were stored in 88 flasks and made up 8.8 litres of blood.

The team – funded by the Wellcome Trust and incorporating universities and organisations from around the UK – is now able to produce the cells in 30-31 days. "We can choose what blood group we make," Mountford told the audience at WIRED Health.

Read more: Scientists are growing billions of blood cells in the lab

The NHS Blood and Transplant facility in Bristol, where donated blood is screened. A British team
called Novosang wants to render this process obsolete

Source: Greg White

Human sperm created from mature skin cells for infertility solution

Scientists in Spain say they have created human sperm from skin cells, which could eventually lead to a treatment for infertility.

The researchers said they were working to find a solution for the roughly 15 per cent of couples worldwide who are unable to have children and whose only option is to use donated gametes (sperm or eggs).

"What to do when someone who wants to have a child lacks gametes?" asked Dr Carlos Simon, scientific director of the Valencian Infertility Institute, Spain's first medical institution fully dedicated to assisted reproduction.

"This is the problem we want to address: to be able to create gametes in people who do not have them."

The result of their research, which was carried out with Stanford University in the United States, was published on Tuesday in Scientific Reports, the online journal of Nature.

Read more: Human sperm created from mature skin cells for infertility solution

Infertile sperm cells were created by adding genes to skin cells

Source: ABC News Breakfast