Biochemistry Lecture Notes - Uremia: Background, Pathophysiology, Etiology

Background

Uremia is a clinical syndrome associated with fluid, electrolyte, and hormone imbalances and metabolic abnormalities, which develop in parallel with deterioration of renal function. The term uremia, which literally means urine in the blood, was first used by Piorry to describe the clinical condition associated with renal failure.

Uremia more commonly develops with chronic kidney disease (CKD), especially the later stages, of CKD, but it also may occur with acute kidney injury (AKI) if loss of renal function is rapid. As yet, no single uremic toxin has been identified that accounts for all of the clinical manifestations of uremia. A number of toxins, such as parathyroid hormone (PTH), beta2 microglobulin, polyamines, advanced glycosylation end products, and other middle molecules, are thought to contribute to the clinical syndrome.

Read more: Biochemistry Lecture Notes - Uremia: Background, Pathophysiology, Etiology

Source: Medscape

Biochemistry Lecture Notes - Azotemia: Background, Pathophysiology, Etiology

Background

Azotemia is an elevation of blood urea nitrogen (BUN) and serum creatinine levels. The reference range for BUN is 8-20 mg/dL, and the normal range for serum creatinine is 0.7-1.4 mg/dL.

Each human kidney contains approximately 1 million functional units known as nephrons, which are primarily involved in urine formation. Urine formation ensures that the body eliminates the final products of metabolic activities and excess water in an attempt to maintain a constant internal environment (homeostasis). Urine formation by each nephron involves 3 main processes, as follows: 

• Filtration at the glomerular level 
• Selective reabsorption from the filtrate passing along the renal tubules 
• Secretion by the cells of the tubules into this filtrate 

Perturbation of any of these processes impairs the kidney’s excretory function, resulting in azotemia.

Read more: Biochemistry Lecture Notes - Azotemia: Background, Pathophysiology, Etiology.

Source: Medscape

Cervical Screening of ‘Limited’ Use in Under 25s

The National Cervical Screening Program (NCSP) has been successful for the most part, except for those aged 20-24, according to a new report from Cancer Council NSW.

Incidence of squamous cell carcinoma and overall cervical cancer rates have declined dramatically in women aged 25-plus since the inception of the program in 1991.

“Squamous cell cancer rates in women aged 25 years or more fell by more than 50% but have now plateaued among women aged 25-69 years,” writes Megan Smith and Professor Karen Canfell in the MJA.

But among those aged 20-24, screening has made no difference to cancer rates.

Read more: Cervical Screening of ‘Limited’ Use in Under 25s

Source: 6minutes

Cancer Awareness Month

With a broken heart 💔 and tears 😢 in my eyes, nothing is more painful than trying to smile and remain positive, but after many tests, being poked and prodded, chemo and radiation, the person physically changes and they suffer with sadness. I know many of you do not give a hoot about this message because, of course, the cancer has not affected you. You do not know what it's like to have fought the fight, or have a loved one who leads or has led a battle against cancer. 💜

For all the men and women I know, I ask you a small favor- I know only some of you will do it. If you know someone who has led a battle against cancer, still struggling, or who passed, please add this to your status for one hour as a mark of support, respect, and remembrance. 💚 ❤️

Copy and paste to support those affected by cancer. Do Not Share. From your phone or tablet, hold your finger on the message to copy and paste.

Source: Facebook

#CancerAwarenessMonth

#screwcancer

Unnecessary Endoscopies Could Be Avoided with Fecal Blood Test

The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications.

Serious colorectal diseases, including colorectal cancer, are difficult to diagnose as the signs and symptoms are not always clear.

Read more: Unnecessary Endoscopies Could Be Avoided with Fecal Blood Test

The Quantum Blue rapid test allow for the immediate measurement of fecal calprotectin
(Photo courtesy of Bühlmann Laboratories).

Source: LabMedica

Sensation of Touch Restored After More Than a Decade of Paralysis

Surgeons have restored the sensation of touch to a paralyzed man using a robotic arm connected to electrodes in his brain.

Twelve years ago a promising science student, Nathan Copeland, was involved in a car accident that left him paralyzed from the neck down. He went from being an active 18-year old to being quadriplegic. He was unable to feel anything from the chest down and could not move his lower arms and legs, so needed assistance with all his daily activities.

Read more: Sensation of Touch Restored After More Than a Decade of Paralysis

Source: NewsMedical

What Does Breast Cancer Feel Like? Lumps and Pain Explained

In breast cancer, abnormal genes cause breast cells to grow uncontrollably and not die off as they normally would.

If these cells grow slowly and don't invade other tissues, they cause benign tumors. These are lumps that are not usually considered dangerous to health.

When abnormal cells grow at a more rapid rate and begin to invade surrounding tissues, they form cancerous tumors. These lumps pose a serious risk and can spread, creating new tumors throughout the body.

Read more: What Does Breast Cancer Feel Like? Lumps and Pain Explained

When breast cancer first appears, it can cause a wide range of different symptoms. Always seek
medical attention if in doubt about possible breast symptoms. Breast cancer can also affect men.

Source: MedicalNewsToday

From 230,000 patients to extinct in 15 years: pathology and new drugs key to defeating hepatitis C

An estimated 230,000 Australians have chronic hepatitis C, and a quarter of cases are undiagnosed.

Hepatitis C inflames the liver and unlike the A and B viruses there is no vaccine available. Pathology is important for diagnosing the virus.

Many people with hepatitis C may not experience symptoms, but left untreated the disease can cause cirrhosis (scarring of the liver), which in a small number of cases can lead to liver cancer.

Read more: From 230,000 patients to extinct in 15 years: pathology and new drugs key to defeating hepatitis C

Source: knowpathology

Sauna: What are the Health Benefits?

Saunas have been used for hundreds of years and still continue to be popular today. Many people enjoy sitting in a sauna to unwind and relax.

Spending time in a sauna can feel good, and there may be additional health benefits to be had beyond relaxation.

Read more: Sauna: What are the Health Benefits?

Many people enjoy relaxing and unwinding in a sauna. Steam rooms involve high humidity and
moist heat as opposed to the dry heat of traditional Finnish saunas. It is vital to drink plenty of
water after using a sauna.

Source: MedicalNewsToday

A Lab Manager's Guide to Getting Ahead

Being motivated and showing resourcefulness are what separate a star from the pack

Hard Work, Resourcefulness, and Great Mentors Required

When Lydia Coleman was 25 years old and worked as a staff member in a laboratory, before a surveyor’s visit she asked her then-boss whether managers had done anything in advance to prepare for the survey and had thought about what kinds of questions might arise. Coleman’s boss immediately realized that her employee’s questions showed initiative and enthusiasm for making the workplace run more smoothly, and she expressed her opinion of what a good idea that was. Six years later, Coleman had showed so much enterprise and learned enough to apply for and land a laboratory supervisor’s position, and for the past 35 years she has been either a manager or a director in the health care laboratory industry.

Read more: A Lab Manager's Guide to Getting Ahead

Source: LabManager