If You Are In Danger Of BREAST CANCER, Your Body Will Give You These 5 Signs!

Invasive breast cancer affects 1 in 8 women in the US only. It’s the type of cancer with the highest incidence among women. According to the American Cancer Society, by the end of 2016, 246,660 new cases of invasive breast cancer will be diagnosed in America, 40,450 of which will be terminal.

Detecting the cancer early significantly increases the chances of successful treatment. Knowing the early signs and symptoms of invasive breast cancer can help you detect it in its early stages.

1. FATIGUE

Fatigue is a common symptom in many types of cancer, including breast cancer. The thing is this type of fatigue cannot be alleviated by sleep or rest. Cancer-related fatigue is not caused by physical strain and is often accompanied by other symptoms such as pain, sleep disturbance and depression. This fatigue is caused by an imbalance of chemicals in the body the cancer creates, according to scientists.

Read more: If You Are In Danger Of BREAST CANCER, Your Body Will Give You These 5 Signs!

Source: healthylivingstyle

Watch: Female Breast Exam 

From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

• Cancer cells show increased consumption of and dependence on glutamine.
• Glutamine metabolism fuels the tricarboxylic acid (TCA) cycle, nucleotide and fatty acid biosynthesis, and redox balance in cancer cells.
• Glutamine activates mTOR signaling, suppresses endoplasmic reticulum stress and promotes protein synthesis.

Read more: From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy

Major metabolic and biosynthetic fates of glutamine

Source: NatureReviewsCancer

Download: From Krebs to clinic: glutamine metabolism to cancer therapy.pdf

Study Finds Potential New Biomarker For Cancer Patient Prognosis

To treat or not to treat? That is the question researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing.

Berkeley Lab researchers identified 14 genes regulating genome integrity that were consistently overexpressed in a wide variety of cancers. They then created a scoring system based upon the degree of gene overexpression. For several major types of cancer, including breast and lung cancers, the higher the score, the worse the prognosis. Perhaps more importantly, scores could accurately predict patient response to specific cancer treatments.

The researchers said the findings, to be published Wednesday, Aug. 31, in the journal Nature Communications, could lead to a new biomarker for the early stages of tumor development. The information obtained could help reduce the use of cancer treatments that have a low probability of helping.

Read more: Study Finds Potential New Biomarker For Cancer Patient Prognosis

The centromeres and kinetochores of a chromosome play critical roles during cell division. In mitosis,
microtubule spindle fibers attach to the kinetochores, pulling the chromatids apart. A breakdown in this
process causes chromosome …more

Source: medicalxpress

Early Signs That Cancer Is Growing In Your Body

There’s an important rule about cancer, one of the leading causes of death in the world, and it’s the sooner it’s detected, the higher chances of successful treatment.

Because of that fact, don’t rely on routine tests alone to protect you from cancer. It’s just as important to listen to your body and notice anything that’s different, odd, or unexplainable.

Here are some early signs that are commonly overlooked:

1.Wheezing or shortness of breath

One of the first signs many lung cancer patients remember noticing is the inability to catch their breath.

2.Chronic cough or chest pain

Several types of cancer, including leukemia and lung tumors, can cause symptoms that mimic a bad cough or bronchitis. Some lung cancer patients report chest pain that extends up into the shoulder or down the arm.

Read more: Early Signs That Cancer Is Growing In Your Body

Source: healthiestalternative

The Laser Probe, The iKnife, and The Cutting Edge of Surgery

If the thought of going under the knife fills you with fear, be reassured. No longer is surgery the brutal and hazardous experience faced by our ancestors. Thanks to wonders such as laparoscopy, robotic solutions, and, more recently, the iKnife and the laser probe, surgical intervention is getting safer all the time.

Archaeologists believe that people have been carrying out surgery for up to 11,000 years. Cranial surgery, known as trephination, probably dates back to the Neolithic era. It involved drilling a hole in the skull of a living person.

Speculation suggests it was done to cure disorders such as convulsions, fractures, headaches, and infections. The Ancient Egyptians used the same operation for "letting out" headaches and migraine.

Read more: The Laser Probe, The iKnife, and The Cutting Edge of Surgery

Technological advances make surgery safer and more precise all the time. In robotic surgery, the surgeon
controls the instruments from a console. MRI-guided surgery shows where the tumor is, but the iKnife
can detect its exact borders.

Source: medicalnewstoday

Throat Cancer: Get the Facts

The throat is often described as having many different parts. This article looks at two of the more common places throat cancer can occur: the pharynx and the larynx.

1. The pharynx is most commonly thought of as the throat. It is a tube around 5 inches long that leads from behind the nose to the food pipe.
2. 
   
3. The larynx is also known as the voicebox. It is a short passage just below the pharynx. The larynx holds the vocal cords and a small piece of tissue called the epiglottis.

The epiglottis moves to cover the top of the larynx so food cannot enter it when people breathe.

Read more: Throat Cancer: Get the Facts

Cancer in the throat is uncommon when compared with other forms of cancer. Early symptoms of
throat cancer include a long-lasting cough and pain when swallowing.

Source: medicalnewstoday

Colorecal Cancer: Minimally Invasive, Triple-Therapy Patch Destroys Tumors

Research released by the Massachusetts Institute of Technology describes an adhesive patch that can deliver a triple-combination of drug, gene, and light-based therapy to colorectal tumors.

Colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. The lifetime risk of developing colorectal cancer is 1 in 21 for men and 1 in 23 for women.

Most colorectal cancers begin as a growth, or tumor, on the inner lining of the colon or rectum called a polyp, and they can change to cancer over many years. Not all polyps become cancer.

It usually takes around 10-15 years for abnormal cells to grow into colorectal tumors. With regular screening, polyps can be removed before they develop into cancer.

Although the type of treatment for colorectal cancer largely depends on the stage of cancer, treatment options are often surgery, chemotherapy, and radiation therapy.

Read more: Colorecal Cancer: Minimally Invasive, Triple-Therapy Patch Destroys Tumors

The triple-therapy patch could be used to treat any remaining cancer cells at the tumor site after surgery.

Source: medicalnewstoday

Amazing Foods That Help Prevent Fatty Liver

Have you been suffering from abdominal pain, nausea, vomiting, fatigue and loss of appetite quite often?

Then, you need to watch out, as these could be the symptoms of a fatty liver disease. In case of fatty liver disease, one tends to develop excess fats within the liver.

Liver is one of the most important vital organs of our body. A certain amount of fat in the liver is normal, but when it increases above the normal (above 5 per cent of the organ's weight), then the person could be at the risk of developing fatty liver disease.

Read more: Amazing Foods That Help Prevent Fatty Liver

Source: boldsky

Compounds Detected in Breath Samples Specific to Ovarian Cancer

Diagnosing cancer today usually involves various imaging techniques, examining tissue samples under a microscope, or testing cells for proteins or genetic material. 

In search of safer and less invasive ways to tell if someone has cancer, analyzing breath and defining specific profiles of compounds in breath samples is under investigation, but translating these exhaled disease fingerprints into a meaningful diagnosis has required a large number of sensors, which makes them impractical for clinical use.

Read more: Compounds Detected in Breath Samples Specific to Ovarian Cancer

Schematic representation of analysis of breath samples for the diagnosis of ovarian cancer

Source: clinchemlabmedica

H. Pylori: Know the Facts

Helicobacter pylori, commonly called H. pylori, is a type of bacteria that can infect the stomach and small bowel. It was discovered in 1982 by two Australian researchers who found that it causes peptic ulcer disease.

Peptic ulcers are open sores in the lining of the stomach or the upper part of the small intestine. Peptic ulcers are often called "ulcers" or "stomach ulcers."

For years, medical experts believed that peptic ulcers were caused by stress or certain foods. After the discovery of H. pylori, however, this belief was put to rest. A study in Digestive and Liver Disease suggests that 60 to nearly 100 percent of peptic ulcers are associated with H. pylori.

Read more: H. Pylori: Know the Facts

H. pylori bacteria attack the protective lining of the stomach, causing ulcer, that can be diagnosed
with an endoscopy.

Source: medicalnewstoday

New 'Mutation-Tracking' Blood Test Could Predict Breast Cancer Relapse Months in Advance

Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans.

The test can uncover small numbers of residual cancer cells that have resisted therapy by detecting cancer DNA in the bloodstream.

Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust were able to track key mutations that cancer accumulates as it develops and spreads, without the need for invasive biopsy procedures.

They hope that by deciphering the DNA code found in blood samples, it should be possible to identify the particularly mutations likely to prove lethal to that patient - and tailor treatment accordingly.

Read more: New 'Mutation-Tracking' Blood Test Could Predict Breast Cancer Relapse Months in Advance

Source: medicalxpress

Prostate Cancer And DNA Mutation: New Connections Revealed

Specific mutations in the DNA of men with metastatic prostate cancer have been shown to play a larger role in the disease than previously thought. Researchers hope that this finding will help change standard therapy guidelines and open the door to drugs currently being used for other cancers.

The new study, published in the New England Journal of Medicine, examined inherited mutations in DNA repair genes.

These gene mutations were already known to occur more frequently in prostate cancer patients than the general population.

However, the present study demonstrated that mutations in DNA repair genes were even more prevalent in people with metastatic prostate cancer, specifically.

Read more: Prostate Cancer And DNA Mutation: New Connections Revealed

Gene mutation research gives a new perspective on prostate cancer.

Source: medicalnewstoday

BRCA1 Gene Mutation May Raise Risk of Aggressive Endometrial Cancer

The risk of aggressive serous or serous-like endometrial cancer may be higher for women with a BRCA1 gene mutation, even after undergoing risk-reducing surgery involving the removal of the fallopian tubes and ovaries. This is the finding of a new study published in JAMA Oncology.

However, the study found that a mutated BRCA1 gene did not increase women's overall risk of uterine cancer if they had undergone the risk-reducing procedure, called risk-reducing salpingo-oophorectomy (RRSO).

RRSO is the surgical removal of the fallopian tube and ovaries, and it is sometimes recommended for women who are at high risk of breast or ovarian cancers as a result of BRCA1 or BRCA2 gene mutations.

Read more: BRCA1 Gene Mutation May Raise Risk of Aggressive Endometrial Cancer

Researchers say women with a BRCA1 mutation are at higher risk for aggressive endometrial cancer,
even after undergoing risk-reducing surgery.

Source: medicalnewstoday.

Cancer Breakthrough? Novel Insight into Metastasis Could Offer New Treatments

Researchers from the United Kingdom may have made a breakthrough in cancer treatment, after discovering an unusual mechanism by which cancer cells spread and survive in the body.

In a study published in Nature Communications, researchers reveal how two molecules join forces to help cancer cells survive as they metastasize.

Metastasis is the process by which cancer cells break away from the primary tumor and spread to other parts of the body through the bloodstream or lymph system.

Once cancer has spread, the disease becomes much more challenging to treat Chemotherapy, hormone therapy, radiotherapy, and other treatments can yield success for some metastatic cancers, but for most, the prognosis is poor.

Read more: Cancer Breakthrough? Novel Insight into Metastasis Could Offer New Treatments

Source: medicalnewstoday

How Red Meat Can Affect Cancer Risk

You may have heard the news recently that researchers have found links between eating red meat and increased risk of certain cancers. But what does this mean for you? Should you say good-bye forever to burgers, steaks and bacon?

These latest concerns are based on an October 2015 report from the World Health Organization (WHO), which had 22 experts in 10 countries review about 800 epidemiological studies to look for a connection between red meat and processed meats and cancer. It found heightened risk between these meats—especially processed meats—and some cancers, particularly colorectal cancer.

WHO didn’t say you should ban red meat or processed meats from your diet completely, but it did advise limiting the amount you eat. Here are some of the key findings from the WHO study.

Read more: How Red Meat Can Affect Cancer Risk

Source: healthgrades

Do You Know All The Chemicals In Cigarette Smoke? Most People Don’t

Cigarette smoke is packed with thousands of chemicals, but most people aren’t even aware of them.

There are some 4,800 chemicals in cigarette smoke, many of which are carcinogens — yet the majority of people who smoke don’t realize what they’re inhaling. A new study published in the journal BMC Public Health argues that making information about cigarette smoke more available to consumers could improve public health and awareness about the dangers of smoking.

“The majority of the [United States] public wants easy access to information about chemicals in cigarettes and other tobacco products,” said Marcella Boynton, lead author of the study, in a press release. “Surprisingly, our results reveal that groups one might presume to be the least psychologically motivated to look for this information, young adults and smokers, were more likely to say that they had previously looked for this information.”

Read more: Do You Know All The Chemicals In Cigarette Smoke? Most People Don’t

Source: healthguru

Breast Cancer Treatment Breakthrough After 'Milestone' Genetic Discovery

The latest breast cancer research could lead to more personalized care for patients and help further understanding of the causes of the disease, scientists said.

A study involving people from around the world has been hailed as giving a more complete picture of the changes in DNA in breast cancer, providing potential opportunities for new treatments.

A study of 560 breast cancer genomes, or complete genetic codes, turned up five new genes associated with the disease.

Read more: Breast Cancer Treatment Breakthrough After 'Milestone' Genetic Discovery

Source: IndependentPrintLimited

Breast Cancer: Existing Drug Shows Promise for Prevention in High-Risk Women

Researchers have identified an existing drug that they say has the potential to prevent or delay breast cancer for women at high risk of developing the disease.

In a study published the journal Nature Medicine, researchers reveal how the drug denosumab halted the growth of pre-cancerous cells in breast tissue of women with a faulty BRCA1 gene.

Women with a BRCA1 gene mutation are at significantly greater risk for breast and ovarian cancers; around 55-65 percent of women with such a mutation will develop the disease by the age of 70, according to the National Cancer Institute, compared with 12 percent of those in the general population.

Read more:  Breast Cancer: Existing Drug Shows Promise for Prevention in High-Risk Women

Researchers found the drug denosumab stopped the growth of cells that are a precursor to breast cancer
in women with a BRCA1 gene mutation.

Source: medicalnewstoday

Ovarian Cancer: New Imaging Technique Helps Surgeons Remove More of Tumor.

The amount of tumor tissue that is left after surgery is an important factor in ovarian cancer patient survival. Currently, surgeons have to rely on their eyes and hands to find malignant tissue. Now, new research shows how an imaging technique using a new type of fluorescent compound helped surgeons detect and remove nearly 30 percent more ovarian tumor tissue than usual.

The new technique was tested in a small exploratory study led by Leiden University Medical Center (LUMC) in the Netherlands and published in the journal Clinical Cancer Research.

One of the study leaders, Dr. Alexander L. Vahrmeijer, who heads an image-guided surgery group at LUMC, says:

"Surgery is the most important treatment for ovarian cancer, and surgeons mainly have to rely on their naked eyes to identify tumor tissue, which is not optimal."

Read more: Ovarian Cancer: New Imaging Technique Helps Surgeons Remove More of Tumor.

The experimental study shows that the new imaging system helped surgeons remove more tumor
issue in patients with ovarian cancer.

Source: medicalnewstoday

Novel blood test could diagnose diseases with no known antigens

It may one day be possible to identify cancer, autoimmune diseases, and a wealth of other conditions from a single drop of blood, after a team from the University of Pittsburgh reveals the creation of a test that holds promise for such a feat.

In the Journal of Immunological Methods, the researchers explain how they developed a test that may be able to identify diseases for which there are no known microbial causes.

Antigens are substances - such as bacteria, viruses, or chemicals - that induce an immune response in the body, causing the immune system to produce antibodies that target and destroy these foreign invaders.

Read more: Novel blood test could diagnose diseases with no known antigens

Researchers have created a blood test that they say could diagnose a number of diseases with no
known microbial causes.

Source: medicalnewstoday