Biomedical Laboratory Science

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Saturday, September 3, 2016

Study Finds Potential New Biomarker For Cancer Patient Prognosis

To treat or not to treat? That is the question researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing.

Berkeley Lab researchers identified 14 genes regulating genome integrity that were consistently overexpressed in a wide variety of cancers. They then created a scoring system based upon the degree of gene overexpression. For several major types of cancer, including breast and lung cancers, the higher the score, the worse the prognosis. Perhaps more importantly, scores could accurately predict patient response to specific cancer treatments.

The researchers said the findings, to be published Wednesday, Aug. 31, in the journal Nature Communications, could lead to a new biomarker for the early stages of tumor development. The information obtained could help reduce the use of cancer treatments that have a low probability of helping.


The centromeres and kinetochores of a chromosome play critical roles during cell division. In mitosis,
microtubule spindle fibers attach to the kinetochores, pulling the chromatids apart. A breakdown in this
process causes chromosome …more
Source: medicalxpress

Friday, September 2, 2016

Early Signs That Cancer Is Growing In Your Body

There’s an important rule about cancer, one of the leading causes of death in the world, and it’s the sooner it’s detected, the higher chances of successful treatment.

Because of that fact, don’t rely on routine tests alone to protect you from cancer. It’s just as important to listen to your body and notice anything that’s different, odd, or unexplainable.

Here are some early signs that are commonly overlooked:

1.Wheezing or shortness of breath
One of the first signs many lung cancer patients remember noticing is the inability to catch their breath.

2.Chronic cough or chest pain
Several types of cancer, including leukemia and lung tumors, can cause symptoms that mimic a bad cough or bronchitis. Some lung cancer patients report chest pain that extends up into the shoulder or down the arm.



All You Need to Know About the Glucose Tolerance Test

Most of the food people eat is turned directly into glucose when digested, and the body uses it as energy. The pancreas is responsible for making the hormone insulin which helps to get glucose into the cells of the body.

Diabetes is a long-term disease that occurs due to the pancreas not producing enough insulin or the body being unable to use the insulin it produces effectively.

The body is unable to process food properly to use for energy. Glucose builds up in the blood, which can lead to severe health problems.

There are two main types of diabetes. Type 1 diabetes is usually diagnosed in children and young adults and is also known as juvenile diabetes. With type 1 diabetes the body does not produce insulin. 


A glucose tolerance test can be used to screen for type 2 diabetes. Gestational diabetes can occur in
pregnant woman who have never had diabetes but have high blood glucose levels. During the
glucose test, some people may experience nausea, lightheadedness, shortness of breath, and sweating.

The Common Cold and That Dreaded Flu Virus

Here it is again, the cold and flu season when we all head indoors to share our sneezes and viruses. It’s time to get serious about preventing illness, and that means caring for our personal air filter: the nose.

Viruses are the worst seasonal offenders, and colds are the most common virus we pass around. But the influenza virus is so much worse than a cold. Most folks do not really understand the difference between these two illnesses, yet the difference can be deadly.

Influenza, commonly called “the flu,” is caused by the influenza virus. This is a specific respiratory virus quite different than the cold virus. The entire respiratory tract—including the nose, throat, and lungs—becomes infected. The illness is severe and can be life-threatening; children, the elderly, and those who have underlying medical conditions are at greatest risk for complications.



How Much Influence Does Alcohol Have on Female Fertility?

Although abstinence from alcohol is widely recommended when trying to become pregnant, its exact implications for a woman's fertility are not known. A new study published in The BMJ charts the interaction in new detail.

An estimated 24 percent of couples in developed countries take more than 12 months to conceive.

Because drinking alcohol is a pervasive part of modern life, its impact on fertility is of great interest.

An estimated 18.2 percent of American women aged 18-44 engage in binge drinking (more than four drinks in one sitting), three times per month.

More than one drink per day during pregnancy has been linked to low birth weight, fetal alcohol spectrum disorders, and preterm birth.

However, although alcohol is known to influence male and female reproductive systems and the unborn fetus, its influence on fertility is not well understood


A new study looks in detail at alcohol and fertility.

Antibacterial Soaps Aren't Just Ineffective, They're Potentially Dangerous

With a new ban on antibacterial soap, the US government is finally acknowledging that it’s not just ineffective, it’s also dangerous

Fear is a potent marketing tool. Consider how a Listerine advertising campaign in the 1920s literally turned bad breath into a disease (and sold a ton of mouthwash along the way) or the run on potassium iodide in North America after the Fukushima nuclear power plant disaster in 2011.

Then there are antibacterial soaps and body washes, which have targeted—and arguably created—a widespread fear of disease-causing bacteria lurking on every surface of our homes and bodies. Sales of antibacterial soap skyrocketed during the 2009 H1N1 flu sale and have stayed strong since, as brands marketed their antibacterials as scientifically proven to clean better than the stuff you used to keep by your sink.


Lather up, but just use regular soap. (Mariana Bazo/Reuters)
Source: quartz

Chronic Kidney Disease

WHAT IS CHRONIC KIDNEY DISEASE?

The kidneys function as blood filters that drain waste products while retaining other valuable blood contents like proteins. If these filters are damaged, they initially may become “leaky,” and substances like proteins can seep from blood into urine. At later stages, these filters slowly shut down and lose their ability to filter. When kidney impairment lasts for more than 3 months, it is called chronic kidney disease. This process ultimately results in decreased urine production and kidney failure, with buildup of waste products in the blood and body tissues. One common reason for kidney failure in the United States is diabetes.

Sometimes chronic kidney disease is accompanied by high blood pressure, which not only can be caused by kidney damage but also further accelerates kidney injury and is a major reason for the negative effects of chronic kidney disease on other organs, including increased risk of heart disease and stroke, collection of excess body fluids, anemia, weakening of bones, and impairment of the way the body eliminates medications.


It is estimated that 1 in 10 US adults has chronic kidney disease, and many who have
he disease are not aware of it.
Source: jamanetwork

The Laser Probe, The iKnife, and The Cutting Edge of Surgery

If the thought of going under the knife fills you with fear, be reassured. No longer is surgery the brutal and hazardous experience faced by our ancestors. Thanks to wonders such as laparoscopy, robotic solutions, and, more recently, the iKnife and the laser probe, surgical intervention is getting safer all the time.

Archaeologists believe that people have been carrying out surgery for up to 11,000 years. Cranial surgery, known as trephination, probably dates back to the Neolithic era. It involved drilling a hole in the skull of a living person.

Speculation suggests it was done to cure disorders such as convulsions, fractures, headaches, and infections. The Ancient Egyptians used the same operation for "letting out" headaches and migraine.


Technological advances make surgery safer and more precise all the time. In robotic surgery, the surgeon
controls the instruments from a console. MRI-guided surgery shows where the tumor is, but the iKnife
can detect its exact borders.

Cure The Strep Throat in One Day Without Taking Antibiotics

Strep throat is a very common problem, driving countless individuals to see a doctor for antibiotic treatment. But as with virtually all other problems, no drugs are required for strep throat treatment. In fact, there are rather simple and natural solutions for staving off and treating a case of strep. 

Unfortunately, the medical establishment can’t have you recognizing these ridiculously simple solutions for the problem, however, as drug sales and subsequent profit would take a nosedive. To avoid pharmaceutical treatment, you must learn how to treat strep throat naturally yourself.



What is the Function of the Hypothalamus?

The hypothalamus is a small area in the center of the brain that has many jobs. It plays an important role in hormone production and helps to stimulate many important processes in the body.

When the hypothalamus is not working properly, it can cause problems in the body leading to many disorders. Though diseases of the hypothalamus are uncommon, it is important to keep it healthy to keep the risk low.

Contents of this article:
  1. What is the hypothalamus?
  2. Hypothalamus disorders
  3. Diet tips for hypothalamus health

The hypothalamus plays a huge role in both the endocrine and nervous systems. Head injuries impacting
the hypothalamus are the most common cause of hypothalamic disease. Diets high in saturated fats can
influence and alter the function of the hypothalamus.
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